TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
1_MMFPQ 6_ SRHSG 11_ SSHLP 16_ QQLKF 21_ TTSDS 26_ CDRIK 31_ DEFQL 36_ LQAQY 41_ HSLKL 46_ ECDKL 51_ ASEKS 56_ EMQRH 61_ YVMYY 66_ EMSYG 71_ LNIEM 76_ HKQAE 81_ IVKRL 86_ NGICA 91_ QVLPY 96_ LSQEH 101_ QQQVL 106_ GAIER 111_ AKQVT 116_ APELN 121_ SIIRQ 126_ QLQAH 131_ QLSQL 136_ QALAL 141_ PLTPL 146_ PVGLQ 151_ PPSLP 156_ AVSAG 161_ TGLLS 166_ LSALG 171_ SQAHL 176_ SKEDK 181_ NGHDG 186_ DTHQE 191_DDGEK
1: Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development