Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
1_MSEPK 6_ AIDPK 11_ LSTTD 16_ RVVKA 21_ VPFPP 26_ SHRLT 31_ AKEVF 36_ DNDGK 41_ PRVDI 46_ LKAHL 51_ MKEGR 56_ LEESV 61_ ALRII 66_ TEGAS 71_ ILRQE 76_ KNLLD 81_ IDAPV 86_ TVCGD 91_ IHGQF 96_ FDLMK 101_ LFEVG 106_ GSPAN 111_ TRYLF 116_ LGDYV 121_ DRGYF 126_ SIECV 131_ LYLWA 136_ LKILY 141_ PKTLF 146_ LLRGN 151_ HECRH 156_ LTEYF 161_ TFKQE 166_ CKIKY 171_ SERVY 176_ DACMD 181_ AFDCL 186_ PLAAL 191_ MNQQF 196_ LCVHG 201_ GLSPE 206_ INTLD 211_ DIRKL 216_ DRFKE 221_ PPAYG 226_ PMCDI 231_ LWSDP 236_ LEDFG 241_ NEKTQ 246_ EHFTH 251_ NTVRG 256_ CSYFY 261_ SYPAV 266_ CEFLQ 271_ HNNLL 276_ SILRA 281_ HEAQD 286_ AGYRM 291_ YRKSQ 296_ TTGFP 301_ SLITI 306_ FSAPN 311_ YLDVY 316_ NNKAA 321_ VLKYE 326_ NNVMN 331_ IRQFN 336_ CSPHP 341_ YWLPN 346_ FMDVF 351_ TWSLP 356_ FVGEK 361_ VTEML 366_ VNVLN 371_ ICSDD 376_ ELGSE 381_ EDGFD 386_ GATAA 391_ ARKEV 396_ IRNKI 401_ RAIGK 406_ MARVF 411_ SVLRE 416_ ESESV 421_ LTLKG 426_ LTPTG 431_ MLPSG 436_ VLSGG 441_ KQTLQ 446_ SATVE 451_ AIEAD 456_ EAIKG 461_ FSPQH 466_ KITSF 471_ EEAKG 476_ LDRIN 481_ ERMPP 486_ RRDAM 491_ PSDAN 496_ LNSIN 501_ KALTS 506_ ETNGT 511_ DSNGS 516_NSSNI
1: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679)