Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)
1_MATGQ 6_ KLMRA 11_ VRVFE 16_ FGGPE 21_ VLKLR 26_ SDIAV 31_ PIPKD 36_ HQVLI 41_ KVHAC 46_ GVNPV 51_ ETYIR 56_ SGTYS 61_ RKPLL 66_ PYTPG 71_ SDVAG 76_ VIEAV 81_ GDNAS 86_ AFKKG 91_ DRVFT 96_ SSTIS 101_ GGYAE 106_ YALAA 111_ DHTVY 116_ KLPEK 121_ LDFKQ 126_ GAAIG 131_ IPYFT 136_ AYRAL 141_ IHSAC 146_ VKAGE 151_ SVLVH 156_ GASGG 161_ VGLAA 166_ CQIAR 171_ AYGLK 176_ ILGTA 181_ GTEEG 186_ QKIVL 191_ QNGAH 196_ EVFNH 201_ REVNY 206_ IDKIK 211_ KYVGE 216_ KGIDI 221_ IIEML 226_ ANVNL 231_ SKDLS 236_ LLSHG 241_ GRVIV 246_ VGSRG 251_ TIEIN 256_ PRDTM 261_ AKESS 266_ IIGVT 271_ LFSST 276_ KEEFQ 281_ QYAAA 286_ LQAGM 291_ EIGWL 296_ KPVIG 301_ SQYPL 306_ EKVAE 311_ AHENI 316_ IHGSG 321_ATGKM
1: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding