Gene name: CACNB2

Uniprot entry:

Q08289

Protein names:

Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)

Protein sequence:

1_MVQRD 6_ MSKSP 11_ PTAAA 16_ AVAQE 21_ IQMEL 26_ LENVA 31_ PAGAL 36_ GAAAQ 41_ SYGKG 46_ ARRKN 51_ RFKGS 56_ DGSTS 61_ SDTTS 66_ NSFVR 71_ QGSAD 76_ SYTSR 81_ PSDSD 86_ VSLEE 91_ DREAV 96_ RREAE 101_ RQAQA 106_ QLEKA 111_ KTKPV 116_ AFAVR 121_ TNVSY 126_ SAAHE 131_ DDVPV 136_ PGMAI 141_ SFEAK 146_ DFLHV 151_ KEKFN 156_ NDWWI 161_ GRLVK 166_ EGCEI 171_ GFIPS 176_ PVKLE 181_ NMRLQ 186_ HEQRA 191_ KQGKF 196_ YSSKS 201_ GGNSS 206_ SSLGD 211_ IVPSS 216_ RKSTP 221_ PSSAI 226_ DIDAT 231_ GLDAE 236_ ENDIP 241_ ANHRS 246_ PKPSA 251_ NSVTS 256_ PHSKE 261_ KRMPF 266_ FKKTE 271_ HTPPY 276_ DVVPS 281_ MRPVV 286_ LVGPS 291_ LKGYE 296_ VTDMM 301_ QKALF 306_ DFLKH 311_ RFEGR 316_ ISITR 321_ VTADI 326_ SLAKR 331_ SVLNN 336_ PSKHA 341_ IIERS 346_ NTRSS 351_ LAEVQ 356_ SEIER 361_ IFELA 366_ RTLQL 371_ VVLDA 376_ DTINH 381_ PAQLS 386_ KTSLA 391_ PIIVY 396_ VKISS 401_ PKVLQ 406_ RLIKS 411_ RGKSQ 416_ AKHLN 421_ VQMVA 426_ ADKLA 431_ QCPPE 436_ LFDVI 441_ LDENQ 446_ LEDAC 451_ EHLAD 456_ YLEAY 461_ WKATH 466_ PPSSS 471_ LPNPL 476_ LSRTL 481_ ATSSL 486_ PLSPT 491_ LASNS 496_ QGSQG 501_ DQRTD 506_ RSAPI 511_ RSASQ 516_ AEEEP 521_ SVEPV 526_ KKSQH 531_ RSSSS 536_ APHHN 541_ HRSGT 546_ SRGLS 551_ RQETF 556_ DSETQ 561_ ESRDS 566_ AYVEP 571_ KEDYS 576_ HDHVD 581_ HYASH 586_ RDHNH 591_ RDETH 596_ GSSDH 601_ RHRES 606_ RHRSR 611_ DVDRE 616_ QDHNE 621_ CNKQR 626_ SRHKS 631_ KDRYC 636_ EKDGE 641_ VISKK 646_ RNEAG 651_EWNRD

Protein annotations

Protein functions:

1: Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370)