Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
1_MAWSL 6_ GSWLG 11_ GCLLV 16_ SALGM 21_ VPPPE 26_ NVRMN 31_ SVNFK 36_ NILQW 41_ ESPAF 46_ AKGNL 51_ TFTAQ 56_ YLSYR 61_ IFQDK 66_ CMNTT 71_ LTECD 76_ FSSLS 81_ KYGDH 86_ TLRVR 91_ AEFAD 96_ EHSDW 101_ VNITF 106_ CPVDD 111_ TIIGP 116_ PGMQV 121_ EVLAD 126_ SLHMR 131_ FLAPK 136_ IENEY 141_ ETWTM 146_ KNVYN 151_ SWTYN 156_ VQYWK 161_ NGTDE 166_ KFQIT 171_ PQYDF 176_ EVLRN 181_ LEPWT 186_ TYCVQ 191_ VRGFL 196_ PDRNK 201_ AGEWS 206_ EPVCE 211_ QTTHD 216_ ETVPS 221_ WMVAV 226_ ILMAS 231_ VFMVC 236_ LALLG 241_ CFALL 246_ WCVYK 251_ KTKYA 256_ FSPRN 261_ SLPQH 266_ LKEFL 271_ GHPHH 276_ NTLLF 281_ FSFPL 286_ SDEND 291_ VFDKL 296_ SVIAE 301_ DSESG 306_ KQNPG 311_ DSCSL 316_GTPPG
1: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state