Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
1_MGPEA 6_ LSSLL 11_ LLLLV 16_ ASGDA 21_ DMKGH 26_ FDPAK 31_ CRYAL 36_ GMQDR 41_ TIPDS 46_ DISAS 51_ SSWSD 56_ STAAR 61_ HSRLE 66_ SSDGD 71_ GAWCP 76_ AGSVF 81_ PKEEE 86_ YLQVD 91_ LQRLH 96_ LVALV 101_ GTQGR 106_ HAGGL 111_ GKEFS 116_ RSYRL 121_ RYSRD 126_ GRRWM 131_ GWKDR 136_ WGQEV 141_ ISGNE 146_ DPEGV 151_ VLKDL 156_ GPPMV 161_ ARLVR 166_ FYPRA 171_ DRVMS 176_ VCLRV 181_ ELYGC 186_ LWRDG 191_ LLSYT 196_ APVGQ 201_ TMYLS 206_ EAVYL 211_ NDSTY 216_ DGHTV 221_ GGLQY 226_ GGLGQ 231_ LADGV 236_ VGLDD 241_ FRKSQ 246_ ELRVW 251_ PGYDY 256_ VGWSN 261_ HSFSS 266_ GYVEM 271_ EFEFD 276_ RLRAF 281_ QAMQV 286_ HCNNM 291_ HTLGA 296_ RLPGG 301_ VECRF 306_ RRGPA 311_ MAWEG 316_ EPMRH 321_ NLGGN 326_ LGDPR 331_ ARAVS 336_ VPLGG 341_ RVARF 346_ LQCRF 351_ LFAGP 356_ WLLFS 361_ EISFI 366_ SDVVN 371_ NSSPA 376_ LGGTF 381_ PPAPW 386_ WPPGP 391_ PPTNF 396_ SSLEL 401_ EPRGQ 406_ QPVAK 411_ AEGSP 416_ TAILI 421_ GCLVA 426_ IILLL 431_ LLIIA 436_ LMLWR 441_ LHWRR 446_ LLSKA 451_ ERRVL 456_ EEELT 461_ VHLSV 466_ PGDTI 471_ LINNR 476_ PGPRE 481_ PPPYQ 486_ EPRPR 491_ GNPPH 496_ SAPCV 501_ PNGSA 506_ LLLSN 511_ PAYRL 516_ LLATY 521_ ARPPR 526_ GPGPP 531_ TPAWA 536_ KPTNT 541_ QAYSG 546_ DYMEP 551_ EKPGA 556_ PLLPP 561_ PPQNS 566_ VPHYA 571_ EADIV 576_ TLQGV 581_ TGGNT 586_ YAVPA 591_ LPPGA 596_ VGDGP 601_ PRVDF 606_ PRSRL 611_ RFKEK 616_ LGEGQ 621_ FGEVH 626_ LCEVD 631_ SPQDL 636_ VSLDF 641_ PLNVR 646_ KGHPL 651_ LVAVK 656_ ILRPD 661_ ATKNA 666_ RNDFL 671_ KEVKI 676_ MSRLK 681_ DPNII 686_ RLLGV 691_ CVQDD 696_ PLCMI 701_ TDYME 706_ NGDLN 711_ QFLSA 716_ HQLED 721_ KAAEG 726_ APGDG 731_ QAAQG 736_ PTISY 741_ PMLLH 746_ VAAQI 751_ ASGMR 756_ YLATL 761_ NFVHR 766_ DLATR 771_ NCLVG 776_ ENFTI 781_ KIADF 786_ GMSRN 791_ LYAGD 796_ YYRVQ 801_ GRAVL 806_ PIRWM 811_ AWECI 816_ LMGKF 821_ TTASD 826_ VWAFG 831_ VTLWE 836_ VLMLC 841_ RAQPF 846_ GQLTD 851_ EQVIE 856_ NAGEF 861_ FRDQG 866_ RQVYL 871_ SRPPA 876_ CPQGL 881_ YELML 886_ RCWSR 891_ ESEQR 896_ PPFSQ 901_ LHRFL 906_AEDAL
1: Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11