Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)
1_MWPQP 6_ RLPPR 11_ PAMSE 16_ ETRQS 21_ KLAAA 26_ KKKLR 31_ EYQQR 36_ NSPGV 41_ PTGAK 46_ KKKKI 51_ KNGSN 56_ PETTT 61_ SGGCH 66_ SPEDT 71_ PKDNA 76_ ATLQP 81_ SDDTV 86_ LPGGV 91_ PSPGA 96_ SLTSM 101_ AASQN 106_ HDADN 111_ VPNLM 116_ DETKT 121_ FSSTE 126_ SLRQL 131_ SQQLN 136_ GLVCE 141_ SATCV 146_ NGEGP 151_ ASSAN 156_ LKDLE 161_ SRYQQ 166_ LAVAL 171_ DSSYV 176_ TNKQL 181_ NITIE 186_ KLKQQ 191_ NQEIT 196_ DQLEE 201_ EKKEC 206_ HQKQG 211_ ALREQ 216_ LQVHI 221_ QTIGI 226_ LVSEK 231_ AELQT 236_ ALAHT 241_ QHAAR 246_ QKEGE 251_ SEDLA 256_ SRLQY 261_ SRRRV 266_ GELER 271_ ALSAV 276_ STQQK 281_ KADRY 286_ NKELT 291_ KERDA 296_ LRLEL 301_ YKNTQ 306_ SNEDL 311_ KQEKS 316_ ELEEK 321_ LRVLV 326_ TEKAG 331_ MQLNL 336_ EELQK 341_ KLEMT 346_ ELLLQ 351_ QFSSR 356_ CEAPD 361_ ANQQL 366_ QQAME 371_ ERAQL 376_ EAHLG 381_ QVMES 386_ VRQLQ 391_ MERDK 396_ YAENL 401_ KGESA 406_ MWRQR 411_ MQQMS 416_ EQVHT 421_ LREEK 426_ ECSMS 431_ RVQEL 436_ ETSLA 441_ ELRNQ 446_ MAEPP 451_ PPEPP 456_ AGPSE 461_ VEQQL 466_ QAEAE 471_ HLRKE 476_ LEGLA 481_ GQLQA 486_ QVQDN 491_ EGLSR 496_ LNREQ 501_ EERLL 506_ ELERA 511_ AELWG 516_ EQAEA 521_ RRQIL 526_ ETMQN 531_ DRTTI 536_ SRALS 541_ QNREL 546_ KEQLA 551_ ELQSG 556_ FVKLT 561_ NENME 566_ ITSAL 571_ QSEQH 576_ VKREL 581_ GKKLG 586_ ELQEK 591_ LSELK 596_ ETVEL 601_ KSQEA 606_ QSLQQ 611_ QRDQY 616_ LGHLQ 621_ QYVAA 626_ YQQLT 631_ SEKEV 636_ LHNQL 641_ LLQTQ 646_ LVDQL 651_ QQQEA 656_ QGKAV 661_ AEMAR 666_ QELQE 671_ TQERL 676_ EAATQ 681_ QNQQL 686_ RAQLS 691_ LMAHP 696_ GEGDG 701_ LDREE 706_ EEDEE 711_ EEEEE 716_ AVAVP 721_ QPMPS 726_ IPEDL 731_ ESREA 736_ MVAFF 741_ NSAVA 746_ SAEEE 751_ QARLR 756_ GQLKE 761_ QRVRC 766_ RRLAH 771_ LLASA 776_ QKEPE 781_ AAAPA 786_ PGTGG 791_ DSVCG 796_ ETHRA 801_ LQGAM 806_ EKLQS 811_ RFMEL 816_ MQEKA 821_ DLKER 826_ VEELE 831_ HRCIQ 836_ LSGET 841_ DTIGE 846_ YIALY 851_ QSQRA 856_ VLKER 861_ HREKE 866_ EYISR 871_ LAQDK 876_ EEMKV 881_ KLLEL 886_ QELVL 891_ RLVGD 896_ RNEWH 901_ GRFLA 906_ AAQNP 911_ ADEPT 916_ SGAPA 921_ PQELG 926_ AANQQ 931_ GDLCE 936_ VSLAG 941_ SVEPA 946_ QGEAR 951_ EGSPR 956_ DNPTA 961_ QQIMQ 966_ LLREM 971_ QNPRE 976_ RPGLG 981_ SNPCI 986_ PFFYR 991_ ADEND 996_EVKIT
1: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401)