Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
1_MPRPR 6_ LLAAL 11_ CGALL 16_ CAPSL 21_ LVALD 26_ ICSKN 31_ PCHNG 36_ GLCEE 41_ ISQEV 46_ RGDVF 51_ PSYTC 56_ TCLKG 61_ YAGNH 66_ CETKC 71_ VEPLG 76_ LENGN 81_ IANSQ 86_ IAASS 91_ VRVTF 96_ LGLQH 101_ WVPEL 106_ ARLNR 111_ AGMVN 116_ AWTPS 121_ SNDDN 126_ PWIQV 131_ NLLRR 136_ MWVTG 141_ VVTQG 146_ ASRLA 151_ SHEYL 156_ KAFKV 161_ AYSLN 166_ GHEFD 171_ FIHDV 176_ NKKHK 181_ EFVGN 186_ WNKNA 191_ VHVNL 196_ FETPV 201_ EAQYV 206_ RLYPT 211_ SCHTA 216_ CTLRF 221_ ELLGC 226_ ELNGC 231_ ANPLG 236_ LKNNS 241_ IPDKQ 246_ ITASS 251_ SYKTW 256_ GLHLF 261_ SWNPS 266_ YARLD 271_ KQGNF 276_ NAWVA 281_ GSYGN 286_ DQWLQ 291_ VDLGS 296_ SKEVT 301_ GIITQ 306_ GARNF 311_ GSVQF 316_ VASYK 321_ VAYSN 326_ DSANW 331_ TEYQD 336_ PRTGS 341_ SKIFP 346_ GNWDN 351_ HSHKK 356_ NLFET 361_ PILAR 366_ YVRIL 371_ PVAWH 376_ NRIAL 381_RLELL
1: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction
2: Main constituent of aortic medial amyloid