Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9)
1_MERLQ 6_ KQPLT 11_ SPGSV 16_ SPSRD 21_ SSVPG 26_ SPSSI 31_ VAKMD 36_ NQVLG 41_ YKDLA 46_ AIPKD 51_ KAILD 56_ IERPD 61_ LMIYE 66_ PHFTY 71_ SLLEH 76_ VELPR 81_ SRERS 86_ LSPKS 91_ TSPPP 96_ SPEVW 101_ ADSRS 106_ PGIIS 111_ QASAP 116_ RTTGT 121_ PRTSL 126_ PHFHH 131_ PETSR 136_ PDSNI 141_ YKKPP 146_ IYKQR 151_ ESVGG 156_ SPQTK 161_ HLIED 166_ LIIES 171_ SKFPA 176_ AQPPD 181_ PNQPA 186_ KIETD 191_ YWPCP 196_ PSLAV 201_ VETEW 206_ RKRKA 211_ SRRGA 216_ EEEEE 221_ EEDDD 226_ SGEEM 231_ KALRE 236_ RQREE 241_ LSKVT 246_ SNLGK 251_ MILKE 256_ EMEKS 261_ LPIRR 266_ KTRSL 271_ PDRTP 276_ FHTSL 281_ HQGTS 286_ KSSSL 291_ PAYGR 296_ TTLSR 301_ LQSTE 306_ FSPSG 311_ SETGS 316_ PGLQN 321_ GEGQR 326_ GRMDR 331_ GNSLP 336_ CVLEQ 341_ KIYPY 346_ EMLVV 351_ TNKGR 356_ TKLPP 361_ GVDRM 366_ RLERH 371_ LSAED 376_ FSRVF 381_ AMSPE 386_ EFGKL 391_ ALWKR 396_NELKK
1: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation