Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
1_MWPLV 6_ AALLL 11_ GSACC 16_ GSAQL 21_ LFNKT 26_ KSVEF 31_ TFCND 36_ TVVIP 41_ CFVTN 46_ MEAQN 51_ TTEVY 56_ VKWKF 61_ KGRDI 66_ YTFDG 71_ ALNKS 76_ TVPTD 81_ FSSAK 86_ IEVSQ 91_ LLKGD 96_ ASLKM 101_ DKSDA 106_ VSHTG 111_ NYTCE 116_ VTELT 121_ REGET 126_ IIELK 131_ YRVVS 136_ WFSPN 141_ ENILI 146_ VIFPI 151_ FAILL 156_ FWGQF 161_ GIKTL 166_ KYRSG 171_ GMDEK 176_ TIALL 181_ VAGLV 186_ ITVIV 191_ IVGAI 196_ LFVPG 201_ EYSLK 206_ NATGL 211_ GLIVT 216_ STGIL 221_ ILLHY 226_ YVFST 231_ AIGLT 236_ SFVIA 241_ ILVIQ 246_ VIAYI 251_ LAVVG 256_ LSLCI 261_ AACIP 266_ MHGPL 271_ LISGL 276_ SILAL 281_ AQLLG 286_ LVYMK 291_ FVASN 296_ QKTIQ 301_ PPRKA 306_ VEEPL 311_ NAFKE 316_SKGMM
1: Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:7691831, PubMed:8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:11509594, PubMed:15383453, PubMed:19004835, PubMed:27742621, PubMed:32679764, PubMed:7691831, PubMed:8550562). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831). May prevent premature elimination of red blood cells (By similarity)