Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
1_MNNFI 6_ LLEEQ 11_ LIKKS 16_ QQKRR 21_ TSPSN 26_ FKVRF 31_ FVLTK 36_ ASLAY 41_ FEDRH 46_ GKKRT 51_ LKGSI 56_ ELSRI 61_ KCVEI 66_ VKSDI 71_ SIPCH 76_ YKYPF 81_ QVVHD 86_ NYLLY 91_ VFAPD 96_ RESRQ 101_ RWVLA 106_ LKEET 111_ RNNNS 116_ LVPKY 121_ HPNFW 126_ MDGKW 131_ RCCSQ 136_ LEKLA 141_ TGCAQ 146_ YDPTK 151_ NASKK 156_ PLPPT 161_ PEDNR 166_ RPLWE 171_ PEETV 176_ VIALY 181_ DYQTN 186_ DPQEL 191_ ALRRN 196_ EEYCL 201_ LDSSE 206_ IHWWR 211_ VQDRN 216_ GHEGY 221_ VPSSY 226_ LVEKS 231_ PNNLE 236_ TYEWY 241_ NKSIS 246_ RDKAE 251_ KLLLD 256_ TGKEG 261_ AFMVR 266_ DSRTA 271_ GTYTV 276_ SVFTK 281_ AVVSE 286_ NNPCI 291_ KHYHI 296_ KETND 301_ NPKRY 306_ YVAEK 311_ YVFDS 316_ IPLLI 321_ NYHQH 326_ NGGGL 331_ VTRLR 336_ YPVCF 341_ GRQKA 346_ PVTAG 351_ LRYGK 356_ WVIDP 361_ SELTF 366_ VQEIG 371_ SGQFG 376_ LVHLG 381_ YWLNK 386_ DKVAI 391_ KTIRE 396_ GAMSE 401_ EDFIE 406_ EAEVM 411_ MKLSH 416_ PKLVQ 421_ LYGVC 426_ LEQAP 431_ ICLVF 436_ EFMEH 441_ GCLSD 446_ YLRTQ 451_ RGLFA 456_ AETLL 461_ GMCLD 466_ VCEGM 471_ AYLEE 476_ ACVIH 481_ RDLAA 486_ RNCLV 491_ GENQV 496_ IKVSD 501_ FGMTR 506_ FVLDD 511_ QYTSS 516_ TGTKF 521_ PVKWA 526_ SPEVF 531_ SFSRY 536_ SSKSD 541_ VWSFG 546_ VLMWE 551_ VFSEG 556_ KIPYE 561_ NRSNS 566_ EVVED 571_ ISTGF 576_ RLYKP 581_ RLAST 586_ HVYQI 591_ MNHCW 596_ KERPE 601_ DRPAF 606_ SRLLR 611_QLAEI
1: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity)