FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
1_MAETL 6_ EFNDV 11_ YQEVK 16_ GSMND 21_ GRLRL 26_ SRQGI 31_ IFKNS 36_ KTGKV 41_ DNIQA 46_ GELTE 51_ GIWRR 56_ VALGH 61_ GLKLL 66_ TKNGH 71_ VYKYD 76_ GFRES 81_ EFEKL 86_ SDFFK 91_ THYRL 96_ ELMEK 101_ DLCVK 106_ GWNWG 111_ TVKFG 116_ GQLLS 121_ FDIGD 126_ QPVFE 131_ IPLSN 136_ VSQCT 141_ TGKNE 146_ VTLEF 151_ HQNDD 156_ AEVSL 161_ MEVRF 166_ YVPPT 171_ QEDGV 176_ DPVEA 181_ FAQNV 186_ LSKAD 191_ VIQAT 196_ GDAIC 201_ IFREL 206_ QCLTP 211_ RGRYD 216_ IRIYP 221_ TFLHL 226_ HGKTF 231_ DYKIP 236_ YTTVL 241_ RLFLL 246_ PHKDQ 251_ RQMFF 256_ VISLD 261_ PPIKQ 266_ GQTRY 271_ HFLIL 276_ LFSKD 281_ EDISL 286_ TLNMN 291_ EEEVE 296_ KRFEG 301_ RLTKN 306_ MSGSL 311_ YEMVS 316_ RVMKA 321_ LVNRK 326_ ITVPG 331_ NFQGH 336_ SGAQC 341_ ITCSY 346_ KASSG 351_ LLYPL 356_ ERGFI 361_ YVHKP 366_ PVHIR 371_ FDEIS 376_ FVNFA 381_ RGTTT 386_ TRSFD 391_ FEIET 396_ KQGTQ 401_ YTFSS 406_ IEREE 411_ YGKLF 416_ DFVNA 421_ KKLNI 426_ KNRGL 431_ KEGMN 436_ PSYDE 441_ YADSD 446_ EDQHD 451_ AYLER 456_ MKEEG 461_ KIREE 466_ NANDS 471_ SDDSG 476_ EETDE 481_ SFNPG 486_ EEEED 491_ VAEEF 496_ DSNAS 501_ ASSSS 506_ NEGDS 511_ DRDEK 516_ KRKQL 521_ KKAKM 526_ AKDRK 531_ SRKKP 536_ VEVKK 541_ GKDPN 546_ APKRP 551_ MSAYM 556_ LWLNA 561_ SREKI 566_ KSDHP 571_ GISIT 576_ DLSKK 581_ AGEIW 586_ KGMSK 591_ EKKEE 596_ WDRKA 601_ EDARR 606_ DYEKA 611_ MKEYE 616_ GGRGE 621_ SSKRD 626_ KSKKK 631_ KKVKV 636_ KMEKK 641_ STPSR 646_ GSSSK 651_ SSSRQ 656_ LSESF 661_ KSKEF 666_ VSSDE 671_ SSSGE 676_ NKSKK 681_ KRRRS 686_ EDSEE 691_ EELAS 696_ TPPSS 701_EDSAS
1: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63