Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
1_MPSGG 6_ DQSPP 11_ PPPPP 16_ PAAAA 21_ SDEEE 26_ EDDGE 31_ AEDAA 36_ PPAES 41_ PTPQI 46_ QQRFD 51_ ELCSR 56_ LNMDE 61_ AARAE 66_ AWDSY 71_ RSMSE 76_ SYTLE 81_ GNDLH 86_ WLACA 91_ LYVAC 96_ RKSVP 101_ TVSKG 106_ TVEGN 111_ YVSLT 116_ RILKC 121_ SEQSL 126_ IEFFN 131_ KMKKW 136_ EDMAN 141_ LPPHF 146_ RERTE 151_ RLERN 156_ FTVSA 161_ VIFKK 166_ YEPIF 171_ QDIFK 176_ YPQEE 181_ QPRQQ 186_ RGRKQ 191_ RRQPC 196_ TVSEI 201_ FHFCW 206_ VLFIY 211_ AKGNF 216_ PMISD 221_ DLVNS 226_ YHLLL 231_ CALDL 236_ VYGNA 241_ LQCSN 246_ RKELV 251_ NPNFK 256_ GLSED 261_ FHAKD 266_ SKPSS 271_ DPPCI 276_ IEKLC 281_ SLHDG 286_ LVLEA 291_ KGIKE 296_ HFWKP 301_ YIRKL 306_ YEKKL 311_ LKGKE 316_ ENLTG 321_ FLEPG 326_ NFGES 331_ FKAIN 336_ KAYEE 341_ YVLSV 346_ GNLDE 351_ RIFLG 356_ EDAEE 361_ EIGTL 366_ SRCLN 371_ AGSGT 376_ ETAER 381_ VQMKN 386_ ILQQH 391_ FDKSK 396_ ALRIS 401_ TPLTG 406_ VRYIK 411_ ENSPC 416_ VTPVS 421_ TATHS 426_ LSRLH 431_ TMLTG 436_ LRNAP 441_ SEKLE 446_ QILRT 451_ CSRDP 456_ TQAIA 461_ NRLKE 466_ MFEIY 471_ SQHFQ 476_ PDEDF 481_ SNCAK 486_ EIASK 491_ HFRFA 496_ EMLYY 501_ KVLES 506_ VIEQE 511_ QKRLG 516_ DMDLS 521_ GILEQ 526_ DAFHR 531_ SLLAC 536_ CLEVV 541_ TFSYK 546_ PPGNF 551_ PFITE 556_ IFDVP 561_ LYHFY 566_ KVIEV 571_ FIRAE 576_ DGLCR 581_ EVVKH 586_ LNQIE 591_ EQILD 596_ HLAWK 601_ PESPL 606_ WEKIR 611_ DNENR 616_ VPTCE 621_ EVMPP 626_ QNLER 631_ ADEIC 636_ IAGSP 641_ LTPRR 646_ VTEVR 651_ ADTGG 656_ LGRSI 661_ TSPTT 666_ LYDRY 671_ SSPPA 676_ STTRR 681_ RLFVE 686_ NDSPS 691_ DGGTP 696_ GRMPP 701_ QPLVN 706_ AVPVQ 711_ NVSGE 716_ TVSVT 721_ PVPGQ 726_ TLVTM 731_ ATATV 736_ TANNG 741_ QTVTI 746_ PVQGI 751_ ANENG 756_ GITFF 761_ PVQVN 766_ VGGQA 771_ QAVTG 776_ SIQPL 781_ SAQAL 786_ AGSLS 791_ SQQVT 796_ GTTLQ 801_ VPGQV 806_ AIQQI 811_ SPGGQ 816_ QQKQG 821_ QSVTS 826_ SSNRP 831_ RKTSS 836_ LSLFF 841_ RKVYH 846_ LAAVR 851_ LRDLC 856_ AKLDI 861_ SDELR 866_ KKIWT 871_ CFEFS 876_ IIQCP 881_ ELMMD 886_ RHLDQ 891_ LLMCA 896_ IYVMA 901_ KVTKE 906_ DKSFQ 911_ NIMRC 916_ YRTQP 921_ QARSQ 926_ VYRSV 931_ LIKGK 936_ RKRRN 941_ SGSSD 946_ SRSHQ 951_ NSPTE 956_ LNKDR 961_ TSRDS 966_ SPVMR 971_ SSSTL 976_ PVPQP 981_ SSAPP 986_ TPTRL 991_ TGANS 996_ DMEEE 1001_ ERGDL 1006_ IQFYN 1011_ NIYIK 1016_ QIKTF 1021_ AMKYS 1026_ QANMD 1031_ APPLS 1036_ PYPFV 1041_ RTGSP 1046_ RRIQL 1051_ SQNHP 1056_ VYISP 1061_ HKNET 1066_ MLSPR 1071_ EKIFY 1076_ YFSNS 1081_ PSKRL 1086_ REINS 1091_ MIRTG 1096_ ETPTK 1101_ KRGIL 1106_ LEDGS 1111_ ESPAK 1116_ RICPE 1121_ NHSAL 1126_ LRRLQ 1131_DVAND
1: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor