Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)
1_MGDAA 6_ DPREM 11_ RKTFI 16_ VPAIK 21_ PFDHY 26_ DFSRA 31_ KIACN 36_ LAWLV 41_ AKAFG 46_ TENVP 51_ EELQE 56_ PFYTD 61_ QYDQE 66_ HIKPP 71_ VVNLL 76_ LSAEL 81_ YCRAG 86_ SLILK 91_ SDAAK 96_ PLLGH 101_ DAVIQ 106_ ALAQK 111_ GLYVT 116_ DQEKL 121_ VTERD 126_ LHKKP 131_ IQMSA 136_ HLAMI 141_ DTLMM 146_ AYTVE 151_ MVSIE 156_ KVIAC 161_ AQQYS 166_ AFFQA 171_ TDLPY 176_ DIEDA 181_ VMYWI 186_ NKVNE 191_ HLKDI 196_ MEQEQ 201_ KLKEH 206_ HTVEA 211_ PGGQK 216_ SPSKW 221_ FWKLV 226_ PARYR 231_ KEQTL 236_ LKQLP 241_ CIPLV 246_ ENLLK 251_ DGTDG 256_ CALAA 261_ LIHFY 266_ CPDVV 271_ RLEDI 276_ CLKET 281_ MSLAD 286_ SLYNL 291_ QLIQE 296_ FCQEY 301_ LNQCC 306_ HFTLE 311_ DMLYA 316_ ASSIK 321_ SNYLV 326_ FMAEL 331_ FWWFE 336_ VVKPS 341_ FVQPR 346_ VVRPQ 351_ GAEPV 356_ KDMPS 361_ IPVLN 366_ AAKRN 371_ VLDSS 376_ SDFPS 381_ SGEGA 386_ TFTQS 391_ HHHLP 396_ SRYSR 401_ PQAHS 406_ SASGG 411_ IRRSS 416_ SMSYV 421_ DGFIG 426_ TWPKE 431_ KRSSV 436_ HGVSF 441_ DISFD 446_ KEDSV 451_ QRSTP 456_ NRGIT 461_ RSISN 466_ EGLTL 471_ NNSHV 476_ SKHIR 481_ KNLSF 486_ KPING 491_ EEEAE 496_ SIEEE 501_ LNIDS 506_ HSDLK 511_ SCVPL 516_ NTNEL 521_ NSNEN 526_ IHYKL 531_ PNGAL 536_ QNRIL 541_ LDEFG 546_ NQIET 551_ PSIEE 556_ ALQII 561_ HDTEK 566_ SPHTP 571_ QPDQI 576_ ANGFF 581_ LHSQE 586_ MSILN 591_ SNIKL 596_ NQSSP 601_ DNVTD 606_ TKGAL 611_ SPITD 616_ NTEVD 621_ TGIHV 626_ PSEDI 631_ PETMD 636_ EDSSL 641_ RDYTV 646_ SLDSD 651_ MDDAS 656_ KFLQD 661_ YDIRT 666_ GNTRE 671_ ALSPC 676_ PSTVS 681_ TKSQP 686_ GSSAS 691_ SSSGV 696_ KMTSF 701_ AEQKF 706_ RKLNH 711_ TDGKS 716_ SGSSS 721_ QKTTP 726_ EGSEL 731_ NIPHV 736_ VAWAQ 741_ IPEET 746_ GLPQG 751_ RDTTQ 756_ LLASE 761_ MVHLR 766_ MKLEE 771_ KRRAI 776_ EAQKK 781_ KMEAA 786_ FTKQR 791_ QKMGR 796_ TAFLT 801_ VVKKK 806_ GDGIS 811_ PLREE 816_ AAGAE 821_ DEKVY 826_ TDRAK 831_ EKESQ 836_ KTDGQ 841_ RSKSL 846_ ADIKE 851_ SMENP 856_ QAKWL 861_ KSPTT 866_ PIDPE 871_ KQWNL 876_ ASPSE 881_ ETLNE 886_ GEILE 891_ YTKSI 896_ EKLNS 901_ SLHFL 906_ QQEMQ 911_ RLSLQ 916_ QEMLM 921_ QMREQ 926_ QSWVI 931_ SPPQP 936_ SPQKQ 941_ IRDFK 946_ PSKQA 951_ GLSSA 956_ IAPFS 961_ SDSPR 966_ PTHPS 971_ PQSSN 976_ RKSAS 981_ FSVKS 986_ QRTPR 991_ PNELK 996_ ITPLN 1001_ RTLTP 1006_ PRSVD 1011_ SLPRL 1016_ RRFSP 1021_ SQVPI 1026_ QTRSF 1031_ VCFGD 1036_ DGEPQ 1041_ LKESK 1046_ PKEEV 1051_ KKEEL 1056_ ESKGT 1061_ LEQRG 1066_ HNPEE 1071_ KEIKP 1076_ FESTV 1081_ SEVLS 1086_ LPVTE 1091_ TVCLT 1096_ PNEDQ 1101_ LNQPT 1106_ EPPPK 1111_ PVFPP 1116_ TAPKN 1121_ VNLIE 1126_ VSLSD 1131_ LKPPE 1136_ KADVP 1141_ VEKYD 1146_ GESDK 1151_ EQFDD 1156_ DQKVC 1161_ CGFFF 1166_ KDDQK 1171_ AENDM 1176_ AMKRA 1181_ ALLEK 1186_ RLRRE 1191_ KETQL 1196_ RKQQL 1201_ EAEME 1206_ HKKEE 1211_ TRRKT 1216_ EEERQ 1221_ KKEDE 1226_ RARRE 1231_ FIRQE 1236_ YMRRK 1241_ QLKLM 1246_ EDMDT 1251_ VIKPR 1256_ PQVVK 1261_ QKKQR 1266_ PKSIH 1271_ RDHIE 1276_ SPKTP 1281_ IKGPP 1286_ VSSLS 1291_ LASLN 1296_ TGDNE 1301_ SVHSG 1306_ KRTPR 1311_ SESVE 1316_ GFLSP 1321_ SRCGS 1326_ RNGEK 1331_ DWENA 1336_ STTSS 1341_ VASGT 1346_ EYTGP 1351_ KLYKE 1356_ PSAKS 1361_ NKHII 1366_ QNALA 1371_ HCCLA 1376_ GKVNE 1381_ GQKKK 1386_ ILEEM 1391_ EKSDA 1396_ NNFLI 1401_ LFRDS 1406_ GCQFR 1411_ SLYTY 1416_ CPETE 1421_ EINKL 1426_ TGIGP 1431_ KSITK 1436_ KMIEG 1441_ LYKYN 1446_ SDRKQ 1451_ FSHIP 1456_ AKTLS 1461_ ASVDA 1466_ ITIHS 1471_ HLWQT 1476_ KRPVT 1481_PKKLL
1: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242)