Protein spire homolog 1 (Spir-1)
1_MAQAA 6_ GPAGG 11_ GEPRT 16_ EAVGG 21_ EGPRE 26_ PGAAG 31_ GAAGG 36_ SRDAL 41_ SLEEI 46_ LRLYN 51_ QPINE 56_ EQAWA 61_ VCYQC 66_ CGSLR 71_ AAARR 76_ RQPRH 81_ RVRSA 86_ AQIRV 91_ WRDGA 96_ VTLAP 101_ AADDA 106_ GEPPP 111_ VAGKL 116_ GYSQC 121_ METEV 126_ IESLG 131_ IIIYK 136_ ALDYG 141_ LKENE 146_ ERELS 151_ PPLEQ 156_ LIDHM 161_ ANTVE 166_ ADGSN 171_ DEGYE 176_ AAEEG 181_ LGDED 186_ EKRKI 191_ SAIRS 196_ YRDVM 201_ KLCAA 206_ HLPTE 211_ SDAPN 216_ HYQAV 221_ CRALF 226_ AETME 231_ LHTFL 236_ TKIKS 241_ AKENL 246_ KKIQE 251_ MEKSD 256_ ESSTD 261_ LEELK 266_ NADWA 271_ RFWVQ 276_ VMRDL 281_ RNGVK 286_ LKKVQ 291_ ERQYN 296_ PLPIE 301_ YQLTP 306_ YEMLM 311_ DDIRC 316_ KRYTL 321_ RKVMV 326_ NGDIP 331_ PRLKK 336_ SAHEI 341_ ILDFI 346_ RSRPP 351_ LNPVS 356_ ARKLK 361_ PTPPR 366_ PRSLH 371_ ERILE 376_ EIKAE 381_ RKLRP 386_ VSPEE 391_ IRRSR 396_ LAMRP 401_ LSMSY 406_ SFDLS 411_ DVTTP 416_ ESTKN 421_ LVESS 426_ MVNGG 431_ LTSQT 436_ KENGL 441_ STSQQ 446_ VPAQR 451_ KKLLR 456_ APTLA 461_ ELDSS 466_ ESEEE 471_ TLHKS 476_ TSSSS 481_ VSPSF 486_ PEEPV 491_ LEAVS 496_ TRKKP 501_ PKFLP 506_ ISSTP 511_ QPERR 516_ QPPQR 521_ RHSIE 526_ KETPT 531_ NVRQF 536_ LPPSR 541_ QSSRS 546_ LEEFC 551_ YPVEC 556_ LALTV 561_ EEVMH 566_ IRQVL 571_ VKAEL 576_ EKYQQ 581_ YKDIY 586_ TALKK 591_ GKLCF 596_ CCRTR 601_ RFSFF 606_ TWSYT 611_ CQFCK 616_ RPVCS 621_ QCCKK 626_ MRLPS 631_ KPYST 636_ LPIFS 641_ LGPSA 646_ LQRGE 651_ SSMRS 656_ EKPST 661_ AHHRP 666_ LRSIA 671_ RFSSK 676_ SKSMD 681_ KSDEE 686_ LQFPK 691_ ELMED 696_ WSTME 701_ VCVDC 706_ KKFIS 711_ EIISS 716_ SRRSL 721_ VLANK 726_ RARLK 731_ RKTQS 736_ FYMSS 741_ PGPSE 746_ YCPSE 751_RTISE
1: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361)