Protein VAC14 homolog (Tax1-binding protein 2)
1_MNPEK 6_ DFAPL 11_ TPNIV 16_ RALND 21_ KLYEK 26_ RKVAA 31_ LEIEK 36_ LVREF 41_ VAQNN 46_ TVQIK 51_ HVIQT 56_ LSQEF 61_ ALSQH 66_ PHSRK 71_ GGLIG 76_ LAACS 81_ IALGK 86_ DSGLY 91_ LKELI 96_ EPVLT 101_ CFNDA 106_ DSRLR 111_ YYACE 116_ ALYNI 121_ VKVAR 126_ GAVLP 131_ HFNVL 136_ FDGLS 141_ KLAAD 146_ PDPNV 151_ KSGSE 156_ LLDRL 161_ LKDIV 166_ TESNK 171_ FDLVS 176_ FIPLL 181_ RERIY 186_ SNNQY 191_ ARQFI 196_ ISWIL 201_ VLESV 206_ PDINL 211_ LDYLP 216_ EILDG 221_ LFQIL 226_ GDNGK 231_ EIRKM 236_ CEVVL 241_ GEFLK 246_ EIKKN 251_ PSSVK 256_ FAEMA 261_ NILVI 266_ HCQTT 271_ DDLIQ 276_ LTAMC 281_ WMREF 286_ IQLAG 291_ RVMLP 296_ YSSGI 301_ LTAVL 306_ PCLAY 311_ DDRKK 316_ SIKEV 321_ ANVCN 326_ QSLMK 331_ LVTPE 336_ DDELD 341_ ELRPG 346_ QRQAE 351_ PTPDD 356_ ALPKQ 361_ EGTAS 366_ GGPDG 371_ SCDSS 376_ FSSGI 381_ SVFTA 386_ ASTER 391_ APVTL 396_ HLDGI 401_ VQVLN 406_ CHLSD 411_ TAIGM 416_ MTRIA 421_ VLKWL 426_ YHLYI 431_ KTPRK 436_ MFRHT 441_ DSLFP 446_ ILLQT 451_ LSDES 456_ DEVIL 461_ KDLEV 466_ LAEIA 471_ SSPAG 476_ QTDDP 481_ GPLDG 486_ PDLQA 491_ SHSEL 496_ QVPTP 501_ GRAGL 506_ LNTSG 511_ TKGLE 516_ CSPST 521_ PTMNS 526_ YFYKF 531_ MINLL 536_ KRFSS 541_ ERKLL 546_ EVRGP 551_ FIIRQ 556_ LCLLL 561_ NAENI 566_ FHSMA 571_ DILLR 576_ EEDLK 581_ FASTM 586_ VHALN 591_ TILLT 596_ STELF 601_ QLRNQ 606_ LKDLK 611_ TLESQ 616_ NLFCC 621_ LYRSW 626_ CHNPV 631_ TTVSL 636_ CFLTQ 641_ NYRHA 646_ YDLIQ 651_ KFGDL 656_ EVTVD 661_ FLAEV 666_ DKLVQ 671_ LIECP 676_ IFTYL 681_ RLQLL 686_ DVKNN 691_ PYLIK 696_ ALYGL 701_ LMLLP 706_ QSSAF 711_ QLLSH 716_ RLQCV 721_ PNPEL 726_ LQTED 731_ SLKAA 736_ PKSQK 741_ ADSPS 746_ IDYAE 751_ LLQHF 756_ EKVQN 761_ KHLEV 766_ RHQRS 771_ GRGDH 776_LDRRV
1: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes