Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)
1_MSAEV 6_ RLRRL 11_ QQLVL 16_ DPGFL 21_ GLEPL 26_ LDLLL 31_ GVHQE 36_ LGASE 41_ LAQDK 46_ YVADF 51_ LQWAE 56_ PIVVR 61_ LKEVR 66_ LQRDD 71_ FEILK 76_ VIGRG 81_ AFSEV 86_ AVVKM 91_ KQTGQ 96_ VYAMK 101_ IMNKW 106_ DMLKR 111_ GEVSC 116_ FREER 121_ DVLVN 126_ GDRRW 131_ ITQLH 136_ FAFQD 141_ ENYLY 146_ LVMEY 151_ YVGGD 156_ LLTLL 161_ SKFGE 166_ RIPAE 171_ MARFY 176_ LAEIV 181_ MAIDS 186_ VHRLG 191_ YVHRD 196_ IKPDN 201_ ILLDR 206_ CGHIR 211_ LADFG 216_ SCLKL 221_ RADGT 226_ VRSLV 231_ AVGTP 236_ DYLSP 241_ EILQA 246_ VGGGP 251_ GTGSY 256_ GPECD 261_ WWALG 266_ VFAYE 271_ MFYGQ 276_ TPFYA 281_ DSTAE 286_ TYGKI 291_ VHYKE 296_ HLSLP 301_ LVDEG 306_ VPEEA 311_ RDFIQ 316_ RLLCP 321_ PETRL 326_ GRGGA 331_ GDFRT 336_ HPFFF 341_ GLDWD 346_ GLRDS 351_ VPPFT 356_ PDFEG 361_ ATDTC 366_ NFDLV 371_ EDGLT 376_ AMVSG 381_ GGETL 386_ SDIRE 391_ GAPLG 396_ VHLPF 401_ VGYSY 406_ SCMAL 411_ RDSEV 416_ PGPTP 421_ MELEA 426_ EQLLE 431_ PHVQA 436_ PSLEP 441_ SVSPQ 446_ DETAE 451_ VAVPA 456_ AVPAA 461_ EAEAE 466_ VTLRE 471_ LQEAL 476_ EEEVL 481_ TRQSL 486_ SREME 491_ AIRTD 496_ NQNFA 501_ SQLRE 506_ AEARN 511_ RDLEA 516_ HVRQL 521_ QERME 526_ LLQAE 531_ GATAV 536_ TGVPS 541_ PRATD 546_ PPSHL 551_ DGPPA 556_ VAVGQ 561_ CPLVG 566_ PGPMH 571_ RRHLL 576_ LPARV 581_ PRPGL 586_ SEALS 591_ LLLFA 596_ VVLSR 601_ AAALG 606_ CIGLV 611_ AHAGQ 616_ LTAVW 621_RRPGA
1: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity