Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
1_MAENV 6_ VEPGP 11_ PSAKR 16_ PKLSS 21_ PALSA 26_ SASDG 31_ TDFGS 36_ LFDLE 41_ HDLPD 46_ ELINS 51_ TELGL 56_ TNGGD 61_ INQLQ 66_ TSLGM 71_ VQDAA 76_ SKHKQ 81_ LSELL 86_ RSGSS 91_ PNLNM 96_ GVGGP 101_ GQVMA 106_ SQAQQ 111_ SSPGL 116_ GLINS 121_ MVKSP 126_ MTQAG 131_ LTSPN 136_ MGMGT 141_ SGPNQ 146_ GPTQS 151_ TGMMN 156_ SPVNQ 161_ PAMGM 166_ NTGMN 171_ AGMNP 176_ GMLAA 181_ GNGQG 186_ IMPNQ 191_ VMNGS 196_ IGAGR 201_ GRQNM 206_ QYPNP 211_ GMGSA 216_ GNLLT 221_ EPLQQ 226_ GSPQM 231_ GGQTG 236_ LRGPQ 241_ PLKMG 246_ MMNNP 251_ NPYGS 256_ PYTQN 261_ PGQQI 266_ GASGL 271_ GLQIQ 276_ TKTVL 281_ SNNLS 286_ PFAMD 291_ KKAVP 296_ GGGMP 301_ NMGQQ 306_ PAPQV 311_ QQPGL 316_ VTPVA 321_ QGMGS 326_ GAHTA 331_ DPEKR 336_ KLIQQ 341_ QLVLL 346_ LHAHK 351_ CQRRE 356_ QANGE 361_ VRQCN 366_ LPHCR 371_ TMKNV 376_ LNHMT 381_ HCQSG 386_ KSCQV 391_ AHCAS 396_ SRQII 401_ SHWKN 406_ CTRHD 411_ CPVCL 416_ PLKNA 421_ GDKRN 426_ QQPIL 431_ TGAPV 436_ GLGNP 441_ SSLGV 446_ GQQSA 451_ PNLST 456_ VSQID 461_ PSSIE 466_ RAYAA 471_ LGLPY 476_ QVNQM 481_ PTQPQ 486_ VQAKN 491_ QQNQQ 496_ PGQSP 501_ QGMRP 506_ MSNMS 511_ ASPMG 516_ VNGGV 521_ GVQTP 526_ SLLSD 531_ SMLHS 536_ AINSQ 541_ NPMMS 546_ ENASV 551_ PSLGP 556_ MPTAA 561_ QPSTT 566_ GIRKQ 571_ WHEDI 576_ TQDLR 581_ NHLVH 586_ KLVQA 591_ IFPTP 596_ DPAAL 601_ KDRRM 606_ ENLVA 611_ YARKV 616_ EGDMY 621_ ESANN 626_ RAEYY 631_ HLLAE 636_ KIYKI 641_ QKELE 646_ EKRRT 651_ RLQKQ 656_ NMLPN 661_ AAGMV 666_ PVSMN 671_ PGPNM 676_ GQPQP 681_ GMTSN 686_ GPLPD 691_ PSMIR 696_ GSVPN 701_ QMMPR 706_ ITPQS 711_ GLNQF 716_ GQMSM 721_ AQPPI 726_ VPRQT 731_ PPLQH 736_ HGQLA 741_ QPGAL 746_ NPPMG 751_ YGPRM 756_ QQPSN 761_ QGQFL 766_ PQTQF 771_ PSQGM 776_ NVTNI 781_ PLAPS 786_ SGQAP 791_ VSQAQ 796_ MSSSS 801_ CPVNS 806_ PIMPP 811_ GSQGS 816_ HIHCP 821_ QLPQP 826_ ALHQN 831_ SPSPV 836_ PSRTP 841_ TPHHT 846_ PPSIG 851_ AQQPP 856_ ATTIP 861_ APVPT 866_ PPAMP 871_ PGPQS 876_ QALHP 881_ PPRQT 886_ PTPPT 891_ TQLPQ 896_ QVQPS 901_ LPAAP 906_ SADQP 911_ QQQPR 916_ SQQST 921_ AASVP 926_ TPTAP 931_ LLPPQ 936_ PATPL 941_ SQPAV 946_ SIEGQ 951_ VSNPP 956_ STSST 961_ EVNSQ 966_ AIAEK 971_ QPSQE 976_ VKMEA 981_ KMEVD 986_ QPEPA 991_ DTQPE 996_ DISES 1001_ KVEDC 1006_ KMEST 1011_ ETEER 1016_ STELK 1021_ TEIKE 1026_ EEDQP 1031_ STSAT 1036_ QSSPA 1041_ PGQSK 1046_ KKIFK 1051_ PEELR 1056_ QALMP 1061_ TLEAL 1066_ YRQDP 1071_ ESLPF 1076_ RQPVD 1081_ PQLLG 1086_ IPDYF 1091_ DIVKS 1096_ PMDLS 1101_ TIKRK 1106_ LDTGQ 1111_ YQEPW 1116_ QYVDD 1121_ IWLMF 1126_ NNAWL 1131_ YNRKT 1136_ SRVYK 1141_ YCSKL 1146_ SEVFE 1151_ QEIDP 1156_ VMQSL 1161_ GYCCG 1166_ RKLEF 1171_ SPQTL 1176_ CCYGK 1181_ QLCTI 1186_ PRDAT 1191_ YYSYQ 1196_ NRYHF 1201_ CEKCF 1206_ NEIQG 1211_ ESVSL 1216_ GDDPS 1221_ QPQTT 1226_ INKEQ 1231_ FSKRK 1236_ NDTLD 1241_ PELFV 1246_ ECTEC 1251_ GRKMH 1256_ QICVL 1261_ HHEII 1266_ WPAGF 1271_ VCDGC 1276_ LKKSA 1281_ RTRKE 1286_ NKFSA 1291_ KRLPS 1296_ TRLGT 1301_ FLENR 1306_ VNDFL 1311_ RRQNH 1316_ PESGE 1321_ VTVRV 1326_ VHASD 1331_ KTVEV 1336_ KPGMK 1341_ ARFVD 1346_ SGEMA 1351_ ESFPY 1356_ RTKAL 1361_ FAFEE 1366_ IDGVD 1371_ LCFFG 1376_ MHVQE 1381_ YGSDC 1386_ PPPNQ 1391_ RRVYI 1396_ SYLDS 1401_ VHFFR 1406_ PKCLR 1411_ TAVYH 1416_ EILIG 1421_ YLEYV 1426_ KKLGY 1431_ TTGHI 1436_ WACPP 1441_ SEGDD 1446_ YIFHC 1451_ HPPDQ 1456_ KIPKP 1461_ KRLQE 1466_ WYKKM 1471_ LDKAV 1476_ SERIV 1481_ HDYKD 1486_ IFKQA 1491_ TEDRL 1496_ TSAKE 1501_ LPYFE 1506_ GDFWP 1511_ NVLEE 1516_ SIKEL 1521_ EQEEE 1526_ ERKRE 1531_ ENTSN 1536_ ESTDV 1541_ TKGDS 1546_ KNAKK 1551_ KNNKK 1556_ TSKNK 1561_ SSLSR 1566_ GNKKK 1571_ PGMPN 1576_ VSNDL 1581_ SQKLY 1586_ ATMEK 1591_ HKEVF 1596_ FVIRL 1601_ IAGPA 1606_ ANSLP 1611_ PIVDP 1616_ DPLIP 1621_ CDLMD 1626_ GRDAF 1631_ LTLAR 1636_ DKHLE 1641_ FSSLR 1646_ RAQWS 1651_ TMCML 1656_ VELHT 1661_ QSQDR 1666_ FVYTC 1671_ NECKH 1676_ HVETR 1681_ WHCTV 1686_ CEDYD 1691_ LCITC 1696_ YNTKN 1701_ HDHKM 1706_ EKLGL 1711_ GLDDE 1716_ SNNQQ 1721_ AAATQ 1726_ SPGDS 1731_ RRLSI 1736_ QRCIQ 1741_ SLVHA 1746_ CQCRN 1751_ ANCSL 1756_ PSCQK 1761_ MKRVV 1766_ QHTKG 1771_ CKRKT 1776_ NGGCP 1781_ ICKQL 1786_ IALCC 1791_ YHAKH 1796_ CQENK 1801_ CPVPF 1806_ CLNIK 1811_ QKLRQ 1816_ QQLQH 1821_ RLQQA 1826_ QMLRR 1831_ RMASM 1836_ QRTGV 1841_ VGQQQ 1846_ GLPSP 1851_ TPATP 1856_ TTPTG 1861_ QQPTT 1866_ PQTPQ 1871_ PTSQP 1876_ QPTPP 1881_ NSMPP 1886_ YLPRT 1891_ QAAGP 1896_ VSQGK 1901_ AAGQV 1906_ TPPTP 1911_ PQTAQ 1916_ PPLPG 1921_ PPPAA 1926_ VEMAM 1931_ QIQRA 1936_ AETQR 1941_ QMAHV 1946_ QIFQR 1951_ PIQHQ 1956_ MPPMT 1961_ PMAPM 1966_ GMNPP 1971_ PMTRG 1976_ PSGHL 1981_ EPGMG 1986_ PTGMQ 1991_ QQPPW 1996_ SQGGL 2001_ PQPQQ 2006_ LQSGM 2011_ PRPAM 2016_ MSVAQ 2021_ HGQPL 2026_ NMAPQ 2031_ PGLGQ 2036_ VGISP 2041_ LKPGT 2046_ VSQQA 2051_ LQNLL 2056_ RTLRS 2061_ PSSPL 2066_ QQQQV 2071_ LSILH 2076_ ANPQL 2081_ LAAFI 2086_ KQRAA 2091_ KYANS 2096_ NPQPI 2101_ PGQPG 2106_ MPQGQ 2111_ PGLQP 2116_ PTMPG 2121_ QQGVH 2126_ SNPAM 2131_ QNMNP 2136_ MQAGV 2141_ QRAGL 2146_ PQQQP 2151_ QQQLQ 2156_ PPMGG 2161_ MSPQA 2166_ QQMNM 2171_ NHNTM 2176_ PSQFR 2181_ DILRR 2186_ QQMMQ 2191_ QQQQQ 2196_ GAGPG 2201_ IGPGM 2206_ ANHNQ 2211_ FQQPQ 2216_ GVGYP 2221_ PQQQQ 2226_ RMQHH 2231_ MQQMQ 2236_ QGNMG 2241_ QIGQL 2246_ PQALG 2251_ AEAGA 2256_ SLQAY 2261_ QQRLL 2266_ QQQMG 2271_ SPVQP 2276_ NPMSP 2281_ QQHML 2286_ PNQAQ 2291_ SPHLQ 2296_ GQQIP 2301_ NSLSN 2306_ QVRSP 2311_ QPVPS 2316_ PRPQS 2321_ QPPHS 2326_ SPSPR 2331_ MQPQP 2336_ SPHHV 2341_ SPQTS 2346_ SPHPG 2351_ LVAAQ 2356_ ANPME 2361_ QGHFA 2366_ SPDQN 2371_ SMLSQ 2376_ LASNP 2381_ GMANL 2386_ HGASA 2391_ TDLGL 2396_ STDNS 2401_ DLNSN 2406_LSQST
1: Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493)
2: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein