Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103)
1_MNPLF 6_ GPNLF 11_ LLQQE 16_ QQGLA 21_ GPLGD 26_ SLGGD 31_ HFAGG 36_ GDLPP 41_ APLSP 46_ AGPAA 51_ YSPPG 56_ PGPAP 61_ PAAMA 66_ LRNDL 71_ GSNIN 76_ VLKTL 81_ NLRFR 86_ CFLAK 91_ VHELE 96_ RRNRL 101_ LEKQL 106_ QQALE 111_ EGKQG 116_ RRGLG 121_ RRDQA 126_ VQTGF 131_ VSPIR 136_ PLGLQ 141_ LGARP 146_ AAVCS 151_ PSARV 156_ LGSPA 161_ RSPAG 166_ PLAPS 171_ AASLS 176_ SSSTS 181_ TSTTY 186_ SSSAR 191_ FMPGT 196_ IWSFS 201_ HARRL 206_ GPGLE 211_ PTLVQ 216_ GPGLS 221_ WVHPD 226_ GVGVQ 231_ IDTIT 236_ PEIRA 241_ LYNVL 246_ AKVKR 251_ ERDEY 256_ KRRWE 261_ EEYTV 266_ RIQLQ 271_ DRVNE 276_ LQEEA 281_ QEADA 286_ CQEEL 291_ ALKVE 296_ QLKAE 301_ LVVFK 306_ GLMSN 311_ NLSEL 316_ DTKIQ 321_ EKAMK 326_ VDMDI 331_ CRRID 336_ ITAKL 341_ CDVAQ 346_ QRNCE 351_ DMIQM 356_ FQVPS 361_ MGGRK 366_ RERKA 371_ AVEED 376_ TSLSE 381_ SEGPR 386_ QPDGD 391_ EEEST 396_ ALSIN 401_ EEMQR 406_ MLNQL 411_ REYDF 416_ EDDCD 421_ SLTWE 426_ ETEET 431_ LLLWE 436_ DFSGY 441_ AMAAA 446_ EAQGE 451_ QEDSL 456_ EKVIK 461_ DTESL 466_ FKTRE 471_ KEYQE 476_ TIDQI 481_ ELELA 486_ TAKND 491_ MNRHL 496_ HEYME 501_ MCSMK 506_ RGLDV 511_ QMETC 516_ RRLIT 521_ QSGDR 526_ KSPAF 531_ TAVPL 536_ SDPPP 541_ PPSEA 546_ EDSDR 551_DVSSD
1: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606)