Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7)
1_MRLLE 6_ RMRKD 11_ WFMVG 16_ IVLAI 21_ AGAKL 26_ EPSIG 31_ VNGGP 36_ LKPEI 41_ TVSYI 46_ AVATI 51_ FFNSG 56_ LSLKT 61_ EELTS 66_ ALVHL 71_ KLHLF 76_ IQIFT 81_ LAFFP 86_ ATIWL 91_ FLQLL 96_ SITPI 101_ NEWLL 106_ KGLQT 111_ VGCMP 116_ PPVSS 121_ AVILT 126_ KAVGG 131_ NEAAA 136_ IFNSA 141_ FGSFL 146_ GIVIT 151_ PLLLL 156_ LFLGS 161_ SSSVP 166_ FTSIF 171_ SQLFM 176_ TVVVP 181_ LIIGQ 186_ IVRRY 191_ IKDWL 196_ ERKKP 201_ PFGAI 206_ SSSVL 211_ LMIIY 216_ TTFCD 221_ TFSNP 226_ NIDLD 231_ KFSLV 236_ LILFI 241_ IFSIQ 246_ LSFML 251_ LTFIF 256_ STRNN 261_ SGFTP 266_ ADTVA 271_ IIFCS 276_ THKSL 281_ TLGIP 286_ MLKIV 291_ FAGHE 296_ HLSLI 301_ SVPLL 306_ IYHPA 311_ QILLG 316_ SVLVP 321_ TIKSW 326_ MVSRQ 331_KGVKL
1: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:29878199, PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate)