F-BAR domain only protein 2
1_MVMAY 6_ FVENF 11_ WGEKN 16_ SGFDV 21_ LYHNM 26_ KHGQI 31_ STKEL 36_ ADFVR 41_ ERATI 46_ EEAYS 51_ RSMTK 56_ LAKSA 61_ SNYSQ 66_ LGTFA 71_ PVWDV 76_ FKTST 81_ EKLAN 86_ CHLDL 91_ VRKLQ 96_ ELIKE 101_ VQKYG 106_ EEQVK 111_ SHKKT 116_ KEEVA 121_ GTLEA 126_ VQTIQ 131_ SITQA 136_ LQKSK 141_ ENYNA 146_ KCVEQ 151_ ERLKK 156_ EGATQ 161_ REIEK 166_ AAVKS 171_ KKATD 176_ TYKLY 181_ VEKYA 186_ LAKAD 191_ FEQKM 196_ TETAQ 201_ KFQDI 206_ EETHL 211_ IHIKE 216_ IIGSL 221_ SNAIK 226_ EIHLQ 231_ IGQVH 236_ EEFIN 241_ NMANT 246_ TVESL 251_ IQKFA 256_ ESKGT 261_ GKERP 266_ GLIEF 271_ EECDT 276_ ASAVE 281_ GIKPR 286_ KRKTF 291_ ALPGI 296_ IKKEK 301_ DAESV 306_ ECPDA 311_ DSLNI 316_ PDVDE 321_ EGYSI 326_ KPETN 331_ QNDTK 336_ ENHFY 341_ SSSDS 346_ DSEDE 351_ EPKKY 356_ RIEIK 361_ PMHPN 366_ NSHHT 371_ MASLD 376_ ELKVS 381_ IGNIT 386_ LSPAI 391_ SRHSP 396_ VQMNR 401_ NLSNE 406_ ELTKS 411_ KPSAP 416_ PNEKG 421_ TSDLL 426_ AWDPL 431_ FGPSL 436_ DSSSS 441_ SSLTS 446_ SSSAR 451_ PTTPL 456_ SVGTI 461_ VPPPR 466_ PASRP 471_ KLTSG 476_ KLSGI 481_ NEIPR 486_ PFSPP 491_ VTSNT 496_ SPPPA 501_ APLAR 506_ AESSS 511_ SISSS 516_ ASLSA 521_ ANTPT 526_ VGVSR 531_ GPSPV 536_ SLGNQ 541_ DTLPV 546_ AVALT 551_ ESVNA 556_ YFKGA 561_ DPTKC 566_ IVKIT 571_ GDMTM 576_ SFPSG 581_ IIKVF 586_ TSNPT 591_ PAVLC 596_ FRVKN 601_ ISRLE 606_ QILPN 611_ AQLVF 616_ SDPSQ 621_ CDSNT 626_ KDFWM 631_ NMQAV 636_ TVYLK 641_ KLSEQ 646_ NPAAS 651_ YYNVD 656_ VLKYQ 661_ VSSNG 666_ IQSTP 671_ LNLAT 676_ YWKCS 681_ ASTTD 686_ LRVDY 691_ KYNPE 696_ AMVAP 701_ SVLSN 706_ IQVVV 711_ PVDGG 716_ VTNMQ 721_ SLPPA 726_ IWNAE 731_ QMKAF 736_ WKLSS 741_ ISEKS 746_ ENGGS 751_ GSLRA 756_ KFDLS 761_ EGPSK 766_ PTTLA 771_ VQFLS 776_ EGSTL 781_ SGVDF 786_ ELVGT 791_ GYRLS 796_ LIKKR 801_FATGR
1: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor