Protein INCA1 (Inhibitor of CDK interacting with cyclin A1)
1_MQVQD 6_ DGVNL 11_ IPFAK 16_ CSRVV 21_ SRSPP 26_ PRLPS 31_ QSLRP 36_ MPQRY 41_ GDVFW 46_ KNLNQ 51_ RPTPT 56_ WLEEQ 61_ HIPPM 66_ LRATG 71_ CSQLG 76_ LYPPE 81_ QLPPP 86_ EMLWR 91_ RKKRR 96_ PCLEG 101_ MQQQG 106_ LGGVP 111_ ARVRA 116_ VTYHL 121_ EDLRR 126_ RQSII 131_ NELKK 136_ AQWGS 141_ SGAAS 146_ EPVVL 151_ GEEGC 156_ GFPST 161_ NEYPD 166_ LEEER 171_ ATYPQ 176_ EEDRF 181_ LTPGR 186_ AQLLW 191_ SPWSP 196_ LDQEE 201_ ACASR 206_ QLHSL 211_ ASFST 216_ VTARR 221_ NPLHN 226_ PWGME 231_LAASE
1: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity)