Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)
1_MAQSP 6_ PPQSL 11_ LGHDH 16_ WIFAQ 21_ GWGWA 26_ GHWDS 31_ TSPAS 36_ SSDSS 41_ GSCPC 46_ DGARG 51_ LPQPQ 56_ PPSCS 61_ SRAAE 66_ AAATT 71_ PRRAR 76_ TGPAG 81_ GQRQS 86_ ASERE 91_ KLRMR 96_ TLARA 101_ LHELR 106_ RFLPP 111_ SLAPA 116_ GQSLT 121_ KIETL 126_ RLAIR 131_ YIGHL 136_ SAVLG 141_ LSEES 146_ LQCRR 151_ RQRGD 156_ AGSPW 161_ GCPLC 166_ PDRGP 171_ AEAQT 176_ QAEGQ 181_ GQGQG 186_ QGQGQ 191_ GQGQG 196_ QGQGQ 201_ GQGQG 206_ RRPGL 211_ VSAVL 216_ AEASW 221_ GSPSA 226_ CPGAQ 231_ AAPER 236_ LGRGV 241_ HDTDP 246_ WATPP 251_ YCPKI 256_ QSPPY 261_ SSQGT 266_ TSDAS 271_ LWTPP 276_ QGCPW 281_ TQSSP 286_ EPRNP 291_ PVPWT 296_ AAPAT 301_ LELAA 306_ VYQGL 311_ SVSPE 316_ PCLSL 321_ GAPSL 326_ LPHPS 331_ CQRLQ 336_ PQTPG 341_ RCWSH 346_ SAEVV 351_ PNSED 356_ QGPGA 361_ AFQLS 366_ EASPP 371_ QSSGL 376_ RFSGC 381_ PELWQ 386_ EDLEG 391_ARLGI
1: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Also regulates the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm