Pejvakin (Autosomal recessive deafness type 59 protein)
1_MFAAA 6_ TKSFV 11_ KQVGD 16_ GGRLV 21_ PVPSL 26_ SEADK 31_ YQPLS 36_ LVVKK 41_ KRCFL 46_ FPRYK 51_ FTSTP 56_ FTLKD 61_ ILLGD 66_ REISA 71_ GISSY 76_ QLLNY 81_ EDESD 86_ VSLYG 91_ RRGNH 96_ IVNDV 101_ GINVA 106_ GSDSI 111_ AVKAS 116_ FGIVT 121_ KHEVE 126_ VSTLL 131_ KEITT 136_ RKINF 141_ DHSLI 146_ RQSRS 151_ SRKAV 156_ LCVVM 161_ ESIRT 166_ TRQCS 171_ LSVHA 176_ GIRGE 181_ AMRFH 186_ FMDEQ 191_ NPKGR 196_ DKAIV 201_ FPAHT 206_ TIAFS 211_ VFELF 216_ IYLDG 221_ AFDLC 226_ VTSVS 231_ KGGFE 236_ REETA 241_ TFALL 246_ YRLRN 251_ ILFER 256_ NRRVM 261_ DVISR 266_ SQLYL 271_ DDLFS 276_ DYYDK 281_ PLSMT 286_ DISLK 291_ EGTHI 296_ RVNLL 301_ NHNIP 306_ KGPCI 311_ LCGMG 316_ NFKRE 321_ TVYGC 326_ FQCSV 331_ DGQKY 336_ VRLHA 341_ VPCFD 346_IWHKR
1: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation