Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]
1_MRRRS 6_ RMLLC 11_ FAFLW 16_ VLGIA 21_ YYMYS 26_ GGGSA 31_ LAGGA 36_ GGGAG 41_ RKEDW 46_ NEIDP 51_ IKKKD 56_ LHHSN 61_ GEEKA 66_ QSMET 71_ LPPGK 76_ VRWPD 81_ FNQEA 86_ YVGGT 91_ MVRSG 96_ QDPYA 101_ RNKFN 106_ QVESD 111_ KLRMD 116_ RAIPD 121_ TRHDQ 126_ CQRKQ 131_ WRVDL 136_ PATSV 141_ VITFH 146_ NEARS 151_ ALLRT 156_ VVSVL 161_ KKSPP 166_ HLIKE 171_ IILVD 176_ DYSND 181_ PEDGA 186_ LLGKI 191_ EKVRV 196_ LRNDR 201_ REGLM 206_ RSRVR 211_ GADAA 216_ QAKVL 221_ TFLDS 226_ HCECN 231_ EHWLE 236_ PLLER 241_ VAEDR 246_ TRVVS 251_ PIIDV 256_ INMDN 261_ FQYVG 266_ ASADL 271_ KGGFD 276_ WNLVF 281_ KWDYM 286_ TPEQR 291_ RSRQG 296_ NPVAP 301_ IKTPM 306_ IAGGL 311_ FVMDK 316_ FYFEE 321_ LGKYD 326_ MMMDV 331_ WGGEN 336_ LEISF 341_ RVWQC 346_ GGSLE 351_ IIPCS 356_ RVGHV 361_ FRKQH 366_ PYTFP 371_ GGSGT 376_ VFARN 381_ TRRAA 386_ EVWMD 391_ EYKNF 396_ YYAAV 401_ PSARN 406_ VPYGN 411_ IQSRL 416_ ELRKK 421_ LSCKP 426_ FKWYL 431_ ENVYP 436_ ELRVP 441_ DHQDI 446_ AFGAL 451_ QQGTN 456_ CLDTL 461_ GHFAD 466_ GVVGV 471_ YECHN 476_ AGGNQ 481_ EWALT 486_ KEKSV 491_ KHMDL 496_ CLTVV 501_ DRAPG 506_ SLIKL 511_ QGCRE 516_ NDSRQ 521_ KWEQI 526_ EGNSK 531_ LRHVG 536_ SNLCL 541_ DSRTA 546_ KSGGL 551_ SVEVC 556_ GPALS 561_ QQWKF 566_TLNLQ
1: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671)