ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (CD antigen CD157)
1_MAAQG 6_ CAASR 11_ LLQLL 16_ LQLLL 21_ LLLLL 26_ AAGGA 31_ RARWR 36_ GEGTS 41_ AHLRD 46_ IFLGR 51_ CAEYR 56_ ALLSP 61_ EQRNK 66_ NCTAI 71_ WEAFK 76_ VALDK 81_ DPCSV 86_ LPSDY 91_ DLFIN 96_ LSRHS 101_ IPRDK 106_ SLFWE 111_ NSHLL 116_ VNSFA 121_ DNTRR 126_ FMPLS 131_ DVLYG 136_ RVADF 141_ LSWCR 146_ QKNDS 151_ GLDYQ 156_ SCPTS 161_ EDCEN 166_ NPVDS 171_ FWKRA 176_ SIQYS 181_ KDSSG 186_ VIHVM 191_ LNGSE 196_ PTGAY 201_ PIKGF 206_ FADYE 211_ IPNLQ 216_ KEKIT 221_ RIEIW 226_ VMHEI 231_ GGPNV 236_ ESCGE 241_ GSMKV 246_ LEKRL 251_ KDMGF 256_ QYSCI 261_ NDYRP 266_ VKLLQ 271_ CVDHS 276_ THPDC 281_ ALKSA 286_ AAATQ 291_ RKAPS 296_ LYTEQ 301_ RAGLI 306_ IPLFL 311_VLASR
1: Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable)