Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
1_MLVVQ 6_ MPFSF 11_ PMAHF 16_ ILFVF 21_ TVSTI 26_ FHVQQ 31_ RLAKI 36_ QAMWE 41_ LPVQI 46_ PVLAS 51_ TSKAL 56_ GPSQL 61_ RGMWT 66_ INAIG 71_ RLGNQ 76_ MGEYA 81_ TLYAL 86_ AKMNG 91_ RPAFI 96_ PAQMH 101_ STLAP 106_ IFRIT 111_ LPVLH 116_ SATAS 121_ RIPWQ 126_ NYHLN 131_ DWMEE 136_ EYRHI 141_ PGEYV 146_ RFTGY 151_ PCSWT 156_ FYHHL 161_ RQEIL 166_ QEFTL 171_ HDHVR 176_ EEAQK 181_ FLRGL 186_ QVNGS 191_ RPGTF 196_ VGVHV 201_ RRGDY 206_ VHVMP 211_ KVWKG 216_ VVADR 221_ RYLQQ 226_ ALDWF 231_ RARYS 236_ SLIFV 241_ VTSNG 246_ MAWCR 251_ ENIDT 256_ SHGDV 261_ VFAGD 266_ GIEGS 271_ PAKDF 276_ ALLTQ 281_ CNHTI 286_ MTIGT 291_ FGIWA 296_ AYLTG 301_ GDTIY 306_ LANYT 311_ LPDSP 316_ FLKIF 321_ KPEAA 326_ FLPEW 331_ TGIAA 336_DLSPL
1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:12692541, PubMed:7876235, PubMed:8018146). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:22068912, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235)