4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.152) (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5) (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase)
1_MDPLG 6_ PAKPQ 11_ WLWRR 16_ CLAGL 21_ LFQLL 26_ VAVCF 31_ FSYLR 36_ VSRDD 41_ ATGSP 46_ RPGLM 51_ AVEPV 56_ TGAPN 61_ GSRCQ 66_ DSMAT 71_ PAHPT 76_ LLILL 81_ WTWPF 86_ NTPVA 91_ LPRCS 96_ EMVPG 101_ AADCN 106_ ITADS 111_ SVYPQ 116_ ADAVI 121_ VHHWD 126_ IMYNP 131_ SANLP 136_ PPTRP 141_ QGQRW 146_ IWFSM 151_ ESPSN 156_ CRHLE 161_ ALDGY 166_ FNLTM 171_ SYRSD 176_ SDIFT 181_ PYGWL 186_ EPWSG 191_ QPAHP 196_ PLNLS 201_ AKTEL 206_ VAWAV 211_ SNWKP 216_ DSARV 221_ RYYQS 226_ LQAHL 231_ KVDVY 236_ GRSHK 241_ PLPKG 246_ TMMET 251_ LSRYK 256_ FYLAF 261_ ENSLH 266_ PDYIT 271_ EKLWR 276_ NALEA 281_ WAVPV 286_ VLGPS 291_ RSNYE 296_ RFLPP 301_ DAFIH 306_ VDDFQ 311_ SPKDL 316_ ARYLQ 321_ ELDKD 326_ HARYL 331_ SYFRW 336_ RETLR 341_ PRSFS 346_ WALAF 351_ CKACW 356_ KLQQE 361_ SRYQT 366_VRSIA
1: Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (PubMed:14718375, PubMed:1740457, PubMed:17604274, PubMed:29593094, PubMed:7721776, PubMed:9737988, PubMed:9737989). Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate (PubMed:17604274, PubMed:7721776). Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage (PubMed:14718375, PubMed:1740457, PubMed:17604274, PubMed:7721776, PubMed:9737988). Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors (PubMed:1740457, PubMed:9737989). Lactose-based structures are also acceptor substrates (PubMed:1740457, PubMed:7721776)