CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.99.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)
1_MVTLR 6_ KRTLK 11_ VLTFL 16_ VLFIF 21_ LTSFF 26_ LNYSH 31_ TMVAT 36_ TWFPK 41_ QMVLE 46_ LSENL 51_ KRLIK 56_ HRPCT 61_ CTHCI 66_ GQRKL 71_ SAWFD 76_ ERFNQ 81_ TMQPL 86_ LTAQN 91_ ALLED 96_ DTYRW 101_ WLRLQ 106_ REKKP 111_ NNLND 116_ TIKEL 121_ FRVVP 126_ GNVDP 131_ MLEKR 136_ SVGCR 141_ RCAVV 146_ GNSGN 151_ LRESS 156_ YGPEI 161_ DSHDF 166_ VLRMN 171_ KAPTA 176_ GFEAD 181_ VGTKT 186_ THHLV 191_ YPESF 196_ RELGD 201_ NVSMI 206_ LVPFK 211_ TIDLE 216_ WVVSA 221_ ITTGT 226_ ISHTY 231_ IPVPA 236_ KIRVK 241_ QDKIL 246_ IYHPA 251_ FIKYV 256_ FDNWL 261_ QGHGR 266_ YPSTG 271_ ILSVI 276_ FSMHV 281_ CDEVD 286_ LYGFG 291_ ADSKG 296_ NWHHY 301_ WENNP 306_ SAGAF 311_ RKTGV 316_ HDADF 321_ ESNVT 326_ ATLAS 331_INKIR
1: A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041, PubMed:31719620). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (By similarity) (PubMed:8027041)