CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (Alpha 2,3-ST 4) (Beta-galactoside alpha-2,3-sialyltransferase 4) (EC 2.4.99.2) (EC 2.4.99.4) (Alpha 2,3-sialyltransferase IV) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (EC 2.4.99.6) (SAT-3) (ST-4) (ST3Gal IV) (ST3GalIV) (ST3GalA.2) (STZ) (Sialyltransferase 4C) (SIAT4-C)
1_MVSKS 6_ RWKLL 11_ AMLAL 16_ VLVVM 21_ VWYSI 26_ SREDR 31_ YIELF 36_ YFPIP 41_ EKKEP 46_ CLQGE 51_ AESKA 56_ SKLFG 61_ NYSRD 66_ QPIFL 71_ RLEDY 76_ FWVKT 81_ PSAYE 86_ LPYGT 91_ KGSED 96_ LLLRV 101_ LAITS 106_ SSIPK 111_ NIQSL 116_ RCRRC 121_ VVVGN 126_ GHRLR 131_ NSSLG 136_ DAINK 141_ YDVVI 146_ RLNNA 151_ PVAGY 156_ EGDVG 161_ SKTTM 166_ RLFYP 171_ ESAHF 176_ DPKVE 181_ NNPDT 186_ LLVLV 191_ AFKAM 196_ DFHWI 201_ ETILS 206_ DKKRV 211_ RKGFW 216_ KQPPL 221_ IWDVN 226_ PKQIR 231_ ILNPF 236_ FMEIA 241_ ADKLL 246_ SLPMQ 251_ QPRKI 256_ KQKPT 261_ TGLLA 266_ ITLAL 271_ HLCDL 276_ VHIAG 281_ FGYPD 286_ AYNKK 291_ QTIHY 296_ YEQIT 301_ LKSMA 306_ GSGHN 311_ VSQEA 316_ LAIKR 321_ MLEMG 326_AIKNL
1: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500)