WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)
1_MLDFL 6_ AENNL 11_ CGQAI 16_ LRIVS 21_ CGNAI 26_ IAELL 31_ RLSEF 36_ IPAVF 41_ RLKDR 46_ ADQQK 51_ YGDII 56_ FDFSY 61_ FKGPE 66_ LWESK 71_ LDAKP 76_ ELQDL 81_ DEEFR 86_ ENNIE 91_ IVTRF 96_ YLAFQ 101_ SVHKY 106_ IVDLN 111_ RYLDD 116_ LNEGV 121_ YIQQT 126_ LETVL 131_ LNEDG 136_ KQLLC 141_ EALYL 146_ YGVML 151_ LVIDQ 156_ KIEGE 161_ VRERM 166_ LVSYY 171_ RYSAA 176_ RSSAD 181_ SNMDD 186_ ICKLL 191_ RSTGY 196_ SSQPG 201_ AKRPS 206_ NYPES 211_ YFQRV 216_ PINES 221_ FISMV 226_ IGRLR 231_ SDDIY 236_ NQVSA 241_ YPLPE 246_ HRSTA 251_ LANQA 256_ AMLYV 261_ ILYFE 266_ PSILH 271_ THQAK 276_ MREIV 281_ DKYFP 286_ DNWVI 291_ SIYMG 296_ ITVNL 301_ VDAWE 306_ PYKAA 311_ KTALN 316_ NTLDL 321_ SNVRE 326_ QASRY 331_ ATVSE 336_ RVHAQ 341_ VQQFL 346_ KEGYL 351_ REEMV 356_ LDNIP 361_ KLLNC 366_ LRDCN 371_ VAIRW 376_ LMLHT 381_ ADSAC 386_ DPNNK 391_ RLRQI 396_ KDQIL 401_ TDSRY 406_ NPRIL 411_ FQLLL 416_ DTAQF 421_ EFILK 426_ EMFKQ 431_ MLSEK 436_ QTKWE 441_ HYKKE 446_ GSERM 451_ TELAD 456_ VFSGV 461_ KPLTR 466_ VEKNE 471_ NLQAW 476_ FREIS 481_ KQILS 486_ LNYDD 491_ STAAG 496_ RKTVQ 501_ LIQAL 506_ EEVQE 511_ FHQLE 516_ SNLQV 521_ CQFLA 526_ DTRKF 531_ LHQMI 536_ RTINI 541_ KEEVL 546_ ITMQI 551_ VGDLS 556_ FAWQL 561_ IDSFT 566_ SIMQE 571_ SIRVN 576_ PSMVT 581_ KLRAT 586_ FLKLA 591_ SALDL 596_ PLLRI 601_ NQANS 606_ PDLLS 611_ VSQYY 616_ SGELV 621_ SYVRK 626_ VLQII 631_ PESMF 636_ TSLLK 641_ IIKLQ 646_ THDII 651_ EVPTR 656_ LDKDK 661_ LRDYA 666_ QLGPR 671_ YEVAK 676_ LTHAI 681_ SIFTE 686_ GILMM 691_ KTTLV 696_ GIIKV 701_ DPKQL 706_ LEDGI 711_ RKELV 716_ KRVAF 721_ ALHRG 726_ LIFNP 731_ RAKPS 736_ ELMPK 741_ LKELG 746_ ATMDG 751_ FHRSF 756_ EYIQD 761_ YVNIY 766_ GLKIW 771_ QEEVS 776_ RIINY 781_ NVEQE 786_ CNNFL 791_ RTKIQ 796_ DWQSM 801_ YQSTH 806_ IPIPK 811_ FTPVD 816_ ESVTF 821_ IGRLC 826_ REILR 831_ ITDPK 836_ MTCHI 841_ DQLNT 846_ WYDMK 851_ THQEV 856_ TSSRL 861_ FSEIQ 866_ TTLGT 871_ FGLNG 876_ LDRLL 881_ CFMIV 886_ KELQN 891_ FLSMF 896_ QKIIL 901_ RDRTV 906_ QDTLK 911_ TLMNA 916_ VSPLK 921_ SIVAN 926_ SNKIY 931_ FSAIA 936_ KTQKI 941_ WTAYL 946_ EAIMK 951_ VGQMQ 956_ ILRQQ 961_ IANEL 966_ NYSCR 971_ FDSKH 976_ LAAAL 981_ ENLNK 986_ ALLAD 991_ IEAHY 996_ QDPSL 1001_ PYPKE 1006_ DNTLL 1011_ YEITA 1016_ YLEAA 1021_ GIHNP 1026_ LNKIY 1031_ ITTKR 1036_ LPYFP 1041_ IVNFL 1046_ FLIAQ 1051_ LPKLQ 1056_ YNKNL 1061_ GMVCR 1066_ KPTDP 1071_ VDWPP 1076_ LVLGL 1081_ LTLLK 1086_ QFHSR 1091_ YTEQF 1096_ LALIG 1101_ QFICS 1106_ TVEQC 1111_ TSQKI 1116_ PEIPA 1121_ DVVGA 1126_ LLFLE 1131_ DYVRY 1136_ TKLPR 1141_ RVAEA 1146_ HVPNF 1151_IFDEF
1: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666)