Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
1_MTLTE 6_ RLREK 11_ ISRAF 16_ YNHGL 21_ LCASY 26_ PIPII 31_ LFTGF 36_ CILAC 41_ CYPLL 46_ KLPLP 51_ GTGPV 56_ EFTTP 61_ VKDYS 66_ PPPVD 71_ SDRKQ 76_ GEPTE 81_ QPEWY 86_ VGAPV 91_ AYVQQ 96_ IFVKS 101_ SVFPW 106_ HKNLL 111_ AVDVF 116_ RSPLS 121_ RAFQL 126_ VEEIR 131_ NHVLR 136_ DSSGI 141_ RSLEE 146_ LCLQV 151_ TDLLP 156_ GLRKL 161_ RNLLP 166_ EHGCL 171_ LLSPG 176_ NFWQN 181_ DWERF 186_ HADPD 191_ IIGTI 196_ HQHEP 201_ KTLQT 206_ SATLK 211_ DLLFG 216_ VPGKY 221_ SGVSL 226_ YTRKR 231_ MVSYT 236_ ITLVF 241_ QHYHA 246_ KFLGS 251_ LRARL 256_ MLLHP 261_ SPNCS 266_ LRAES 271_ LVHVH 276_ FKEEI 281_ GVAEL 286_ IPLVT 291_ TYIIL 296_ FAYIY 301_ FSTRK 306_ IDMVK 311_ SKWGL 316_ ALAAV 321_ VTVLS 326_ SLLMS 331_ VGLCT 336_ LFGLT 341_ PTLNG 346_ GEIFP 351_ YLVVV 356_ IGLEN 361_ VLVLT 366_ KSVVS 371_ TPVDL 376_ EVKLR 381_ IAQGL 386_ SSESW 391_ SIMKN 396_ MATEL 401_ GIILI 406_ GYFTL 411_ VPAIQ 416_ EFCLF 421_ AVVGL 426_ VSDFF 431_ LQMLF 436_ FTTVL 441_ SIDIR 446_ RMELA 451_ DLNKR 456_ LPPEA 461_ CLPSA 466_ KPVGQ 471_ PTRYE 476_ RQLAV 481_ RPSTP 486_ HTITL 491_ QPSSF 496_ RNLRL 501_ PKRLR 506_ VVYFL 511_ ARTRL 516_ AQRLI 521_ MAGTV 526_ VWIGI 531_ LVYTD 536_ PAGLR 541_ NYLAA 546_ QVTEQ 551_ SPLGE 556_ GALAP 561_ MPVPS 566_ GMLPP 571_ SHPDP 576_ AFSIF 581_ PPDAP 586_ KLPEN 591_ QTSPG 596_ ESPER 601_ GGPAE 606_ VVHDS 611_ PVPEV 616_ TWGPE 621_ DEELW 626_ RKLSF 631_ RHWPT 636_ LFSYY 641_ NITLA 646_ KRYIS 651_ LLPVI 656_ PVTLR 661_ LNPRE 666_ ALEGR 671_ HPQDG 676_ RSAWP 681_ PPGPI 686_ PAGHW 691_ EAGPK 696_ GPGGV 701_ QAHGD 706_ VTLYK 711_ VAALG 716_ LATGI 721_ VLVLL 726_ LLCLY 731_ RVLCP 736_ RNYGQ 741_ LGGGP 746_ GRRRR 751_ GELPC 756_ DDYGY 761_ APPET 766_ EIVPL 771_ VLRGH 776_ LMDIE 781_ CLASD 786_ GMLLV 791_ SCCLA 796_ GHVCV 801_ WDAQT 806_ GDCLT 811_ RIPRP 816_ GRQRR 821_ DSGVG 826_ SGLEA 831_ QESWE 836_ RLSDG 841_ GKAGP 846_ EEPGD 851_ SPPLR 856_ HRPRG 861_ PPPPS 866_ LFGDQ 871_ PDLTC 876_ LIDTN 881_ FSAQP 886_ RSSQP 891_ TQPEP 896_ RHRAV 901_ CGRSR 906_ DSPGY 911_ DFSCL 916_ VQRVY 921_ QEEGL 926_ AAVCT 931_ PALRP 936_ PSPGP 941_ VLSQA 946_ PEDEG 951_ GSPEK 956_ GSPSL 961_ AWAPS 966_ AEGSI 971_ WSLEL 976_ QGNLI 981_ VVGRS 986_ SGRLE 991_ VWDAI 996_ EGVLC 1001_ CSSEE 1006_ VSSGI 1011_ TALVF 1016_ LDKRI 1021_ VAARL 1026_ NGSLD 1031_ FFSLE 1036_ THTAL 1041_ SPLQF 1046_ RGTPG 1051_ RGSSP 1056_ ASPVY 1061_ SSSDT 1066_ VACHL 1071_ THTVP 1076_ CAHQK 1081_ PITAL 1086_ KAAAG 1091_ RLVTG 1096_ SQDHT 1101_ LRVFR 1106_ LEDSC 1111_ CLFTL 1116_ QGHSG 1121_ AITTV 1126_ YIDQT 1131_ MVLAS 1136_ GGQDG 1141_ AICLW 1146_ DVLTG 1151_ SRVSH 1156_ VFAHR 1161_ GDVTS 1166_ LTCTT 1171_ SCVIS 1176_ SGLDD 1181_ LISIW 1186_ DRSTG 1191_ IKFYS 1196_ IQQDL 1201_ GCGAS 1206_ LGVIS 1211_ DNLLV 1216_ TGGQG 1221_ CVSFW 1226_ DLNYG 1231_ DLLQT 1236_ VYLGK 1241_ NSEAQ 1246_ PARQI 1251_ LVLDN 1256_ AAIVC 1261_ NFGSE 1266_ LSLVY 1271_VPSVL
1: Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity)