Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
1_MDDSG 6_ ELGGL 11_ ETMET 16_ LTELG 21_ DELTL 26_ GDIDE 31_ MLQFV 36_ SNQVG 41_ EFPDL 46_ FSEQL 51_ CSSFP 56_ GSGGS 61_ GSSSG 66_ SSGSS 71_ SSSSN 76_ GRGSS 81_ SGAVD 86_ PSVQR 91_ SFTQV 96_ TLPSF 101_ SPSAA 106_ SPQAP 111_ TLQVK 116_ VSPTS 121_ VPTTP 126_ RATPI 131_ LQPRP 136_ QPQPQ 141_ PQTQL 146_ QQQTV 151_ MITPT 156_ FSTTP 161_ QTRII 166_ QQPLI 171_ YQNAA 176_ TSFQV 181_ LQPQV 186_ QSLVT 191_ SSQVQ 196_ PVTIQ 201_ QQVQT 206_ VQAQR 211_ VLTQT 216_ ANGTL 221_ QTLAP 226_ ATVQT 231_ VAAPQ 236_ VQQVP 241_ VLVQP 246_ QIIKT 251_ DSLVL 256_ TTLKT 261_ DGSPV 266_ MAAVQ 271_ NPALT 276_ ALTTP 281_ IQTAA 286_ LQVPT 291_ LVGSS 296_ GTILT 301_ TMPVM 306_ MGQEK 311_ VPIKQ 316_ VPGGV 321_ KQLEP 326_ PKEGE 331_ RRTTH 336_ NIIEK 341_ RYRSS 346_ INDKI 351_ IELKD 356_ LVMGT 361_ DAKMH 366_ KSGVL 371_ RKAID 376_ YIKYL 381_ QQVNH 386_ KLRQE 391_ NMVLK 396_ LANQK 401_ NKLLK 406_ GIDLG 411_ SLVDN 416_ EVDLK 421_ IEDFN 426_ QNVLL 431_ MSPPA 436_ SDSGS 441_ QAGFS 446_ PYSID 451_ SEPGS 456_ PLLDD 461_ AKVKD 466_ EPDSP 471_ PVALG 476_ MVDRS 481_ RILLC 486_ VLTFL 491_ CLSFN 496_ PLTSL 501_ LQWGG 506_ AHDSD 511_ QHPHS 516_ GSGRS 521_ VLSFE 526_ SGSGG 531_ WFDWM 536_ MPTLL 541_ LWLVN 546_ GVIVL 551_ SVFVK 556_ LLVHG 561_ EPVIR 566_ PHSRS 571_ SVTFW 576_ RHRKQ 581_ ADLDL 586_ ARGDF 591_ AAAAG 596_ NLQTC 601_ LAVLG 606_ RALPT 611_ SRLDL 616_ ACSLS 621_ WNVIR 626_ YSLQK 631_ LRLVR 636_ WLLKK 641_ VFQCR 646_ RATPA 651_ TEAGF 656_ EDEAK 661_ TSARD 666_ AALAY 671_ HRLHQ 676_ LHITG 681_ KLPAG 686_ SACSD 691_ VHMAL 696_ CAVNL 701_ AECAE 706_ EKIPP 711_ STLVE 716_ IHLTA 721_ AMGLK 726_ TRCGG 731_ KLGFL 736_ ASYFL 741_ SRAQS 746_ LCGPE 751_ HSAVP 756_ DSLRW 761_ LCHPL 766_ GQKFF 771_ MERSW 776_ SVKSA 781_ AKESL 786_ YCAQR 791_ NPADP 796_ IAQVH 801_ QAFCK 806_ NLLER 811_ AIESL 816_ VKPQA 821_ KKKAG 826_ DQEEE 831_ SCEFS 836_ SALEY 841_ LKLLH 846_ SFVDS 851_ VGVMS 856_ PPLSR 861_ SSVLK 866_ SALGP 871_ DIICR 876_ WWTSA 881_ ITVAI 886_ SWLQG 891_ DDAAV 896_ RSHFT 901_ KVERI 906_ PKALE 911_ VTESP 916_ LVKAI 921_ FHACR 926_ AMHAS 931_ LPGKA 936_ DGQQS 941_ SFCHC 946_ ERASG 951_ HLWSS 956_ LNVSG 961_ ATSDP 966_ ALNHV 971_ VQLLT 976_ CDLLL 981_ SLRTA 986_ LWQKQ 991_ ASASQ 996_ AVGET 1001_ YHASG 1006_ AELAG 1011_ FQRDL 1016_ GSLRR 1021_ LAHSF 1026_ RPAYR 1031_ KVFLH 1036_ EATVR 1041_ LMAGA 1046_ SPTRT 1051_ HQLLE 1056_ HSLRR 1061_ RTTQS 1066_ TKHGE 1071_ VDAWP 1076_ GQRER 1081_ ATAIL 1086_ LACRH 1091_ LPLSF 1096_ LSSPG 1101_ QRAVL 1106_ LAEAA 1111_ RTLEK 1116_ VGDRR 1121_ SCNDC 1126_ QQMIV 1131_ KLGGG 1136_TAIAA
1: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062)
2: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062)