Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
1_MEAEE 6_ AQRGA 11_ SPPIS 16_ AIEEF 21_ SIIPE 26_ APMRS 31_ SQVSA 36_ LGLEA 41_ QEDED 46_ PSYKW 51_ REEHR 56_ LSATQ 61_ QSELR 66_ DVCDY 71_ AIETM 76_ PSFPK 81_ EGSAD 86_ VEPNQ 91_ ESLVA 96_ EACDT 101_ PEHWE 106_ AVPQS 111_ LAGRQ 116_ ARTLA 121_ PPELW 126_ ACPIQ 131_ SEHLD 136_ MAPFS 141_ SDLGS 146_ EEEEV 151_ EFWPG 156_ LTSLT 161_ LGSGQ 166_ AEEEE 171_ ETSSD 176_ NSGQT 181_ RYYSP 186_ CEEHP 191_ AETNQ 196_ NEGSE 201_ SGTIR 206_ QGEEL 211_ PPEEL 216_ QESQG 221_ LLHPQ 226_ EVQVL 231_ EEQGQ 236_ QEAGF 241_ RGEGT 246_ LREDV 251_ CADGL 256_ LGEEQ 261_ MIEQV 266_ NDEKG 271_ EQKQK 276_ QEQVQ 281_ DVMLG 286_ RQGER 291_ MGLTG 296_ EPEGL 301_ NDGEW 306_ EQEDM 311_ ERKAQ 316_ GQGGP 321_ EQGEE 326_ RKREL 331_ QVPEE 336_ NRADS 341_ QDEKS 346_ QTFLG 351_ KSEEV 356_ TGKQE 361_ DHGIK 366_ EKGVP 371_ VSGQE 376_ AKEPE 381_ SWDGG 386_ RLGAV 391_ GRARS 396_ REEEN 401_ EHHGP 406_ SMPAL 411_ IAPED 416_ SPHCD 421_ LFPGA 426_ SYLMT 431_ QIPGT 436_ QTESR 441_ AEELS 446_ PAALS 451_ PSLEP 456_ IRCSH 461_ QPISL 466_ LGSFL 471_ TEESP 476_ DKEID 481_ QNSQQ 486_ EESRL 491_ RKGTV 496_ SSQGT 501_ EVVFA 506_ SASVT 511_ PPRTP 516_ DSAPP 521_ SPAEA 526_ YPITP 531_ ASVSA 536_ RPPVA 541_ FPRRE 546_ TSCAA 551_ RAPET 556_ ASAPL 561_ SMDDP 566_ SPCGT 571_ SEMCP 576_ AALYG 581_ FPSTG 586_ TSPPR 591_ PPANS 596_ TGTVQ 601_ HLRSD 606_ SFPGS 611_ HRTEQ 616_ TPDLV 621_ GMLLS 626_ YSHSE 631_ LPQRP 636_ PKPAI 641_ YSSVT 646_ PRRDR 651_ RSGRD 656_ YSTVS 661_ ASPTA 666_ LSTLK 671_ QDSQE 676_ SISNL 681_ ERPSS 686_ PPSIQ 691_ PWVSP 696_ HNPAF 701_ ATESP 706_ AYGSS 711_ PSFVS 716_ MEDVR 721_ IHEPL 726_ PPPPP 731_ QRRDT 736_ HPSVV 741_ ETDGH 746_ ARVVV 751_ PTLKQ 756_ HSHPP 761_ PLALG 766_ SGLHA 771_ PHKGP 776_ LPQAS 781_ DPAVA 786_ RQHRP 791_ LPSTP 796_ DSSHH 801_ AQATP 806_ RWRYN 811_ KPLPP 816_ TPDLP 821_ QPHLP 826_ PISAP 831_ GSSRI 836_ YRPLP 841_ PLPII 846_ DPPTE 851_ PPPLP 856_ PKSRG 861_ RSRST 866_ RGGHM 871_ NSGGH 876_ AKTRP 881_ ACQDW 886_ TVPLP 891_ ASAGR 896_ TSWPP 901_ ATARS 906_ TESFT 911_ STSRS 916_ KSEVS 921_ PGMAF 926_ SNMTN 931_ FLCPS 936_ SPTTP 941_ WTPEL 946_ QGPTS 951_ KDEAG 956_ VSEHP 961_ EAPAR 966_ EPLRR 971_ TTPQQ 976_ GASGP 981_ GRSPV 986_ GQARQ 991_ PEKPS 996_ HLHLE 1001_ KASSW 1006_ PHRRD 1011_ SGRPP 1016_ GDSSG 1021_ QAVAP 1026_ SEGAN 1031_ KHKGW 1036_ SRQGL 1041_ RRPSI 1046_ LPEGS 1051_ SDSRG 1056_ PAVEK 1061_ HPGPS 1066_ DTVVF 1071_ REKKP 1076_ KEVMG 1081_ GFSRR 1086_ CSKLI 1091_ NSSQL 1096_ LYQEY 1101_ SDVVL 1106_ NKEIQ 1111_ SQQRL 1116_ ESLSE 1121_ TPGPS 1126_ SPRQP 1131_ RKALV 1136_ SSESY 1141_ LQRLS 1146_ MASSG 1151_ SLWQE 1156_ IPVVR 1161_ NSTVL 1166_ LSMTH 1171_ EDQKL 1176_ QEVKF 1181_ ELIVS 1186_ EASYL 1191_ RSLNI 1196_ AVDHF 1201_ QLSTS 1206_ LRATL 1211_ SNQEH 1216_ QWLFS 1221_ RLQDV 1226_ RDVSA 1231_ TFLSD 1236_ LEENF 1241_ ENNIF 1246_ SFQVC 1251_ DVVLN 1256_ HAPDF 1261_ RRVYL 1266_ PYVTN 1271_ QTYQE 1276_ RTFQS 1281_ LMNSN 1286_ SNFRE 1291_ VLEKL 1296_ ESDPV 1301_ CQRLS 1306_ LKSFL 1311_ ILPFQ 1316_ RITRL 1321_ KLLLQ 1326_ NILKR 1331_ TQPGS 1336_ SEEAE 1341_ ATKAH 1346_ HALEQ 1351_ LIRDC 1356_ NNNVQ 1361_ SMRRT 1366_ EELIY 1371_ LSQKI 1376_ EFECK 1381_ IFPLI 1386_ SQSRW 1391_ LVKSG 1396_ ELTAL 1401_ EFSAS 1406_ PGLRR 1411_ KLNTR 1416_ PVHLH 1421_ LFNDC 1426_ LLLSR 1431_ PREGS 1436_ RFLVF 1441_ DHAPF 1446_ SSIRG 1451_ EKCEM 1456_ KLHGP 1461_ HKNLF 1466_ RLFLR 1471_ QNTQG 1476_ AQAEF 1481_ LFRTE 1486_ TQSEK 1491_ LRWIS 1496_ ALAMP 1501_ REELD 1506_ LLECY 1511_ NSPQV 1516_ QCLRA 1521_ YKPRE 1526_ NDELA 1531_ LEKAD 1536_ VVMVT 1541_ QQSSD 1546_ GWLEG 1551_ VRLSD 1556_ GERGW 1561_ FPVQQ 1566_ VEFIS 1571_ NPEVR 1576_ AQNLK 1581_ EAHRV 1586_ KTAKL 1591_QLVEQ
1: Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity)