Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
1_MANGG 6_ GGGGG 11_ SSGGG 16_ GGGGG 21_ SSLRM 26_ SSNIH 31_ ANHLS 36_ LDASS 41_ SSSSS 46_ SSSSS 51_ SSSSS 56_ SSSSS 61_ VHEPK 66_ MDALI 71_ IPVTM 76_ EVPCD 81_ SRGQR 86_ MWWAF 91_ LASSM 96_ VTFFG 101_ GLFII 106_ LLWRT 111_ LKYLW 116_ TVCCH 121_ CGGKT 126_ KEAQK 131_ INNGS 136_ SQADG 141_ TLKPV 146_ DEKEE 151_ AVAAE 156_ VGWMT 161_ SVKDW 166_ AGVMI 171_ SAQTL 176_ TGRVL 181_ VVLVF 186_ ALSIG 191_ ALVIY 196_ FIDSS 201_ NPIES 206_ CQNFY 211_ KDFTL 216_ QIDMA 221_ FNVFF 226_ LLYFG 231_ LRFIA 236_ ANDKL 241_ WFWLE 246_ VNSVV 251_ DFFTV 256_ PPVFV 261_ SVYLN 266_ RSWLG 271_ LRFLR 276_ ALRLI 281_ QFSEI 286_ LQFLN 291_ ILKTS 296_ NSIKL 301_ VNLLS 306_ IFIST 311_ WLTAA 316_ GFIHL 321_ VENSG 326_ DPWEN 331_ FQNNQ 336_ ALTYW 341_ ECVYL 346_ LMVTM 351_ STVGY 356_ GDVYA 361_ KTTLG 366_ RLFMV 371_ FFILG 376_ GLAMF 381_ ASYVP 386_ EIIEL 391_ IGNRK 396_ KYGGS 401_ YSAVS 406_ GRKHI 411_ VVCGH 416_ ITLES 421_ VSNFL 426_ KDFLH 431_ KDRDD 436_ VNVEI 441_ VFLHN 446_ ISPNL 451_ ELEAL 456_ FKRHF 461_ TQVEF 466_ YQGSV 471_ LNPHD 476_ LARVK 481_ IESAD 486_ ACLIL 491_ ANKYC 496_ ADPDA 501_ EDASN 506_ IMRVI 511_ SIKNY 516_ HPKIR 521_ IITQM 526_ LQYHN 531_ KAHLL 536_ NIPSW 541_ NWKEG 546_ DDAIC 551_ LAELK 556_ LGFIA 561_ QSCLA 566_ QGLST 571_ MLANL 576_ FSMRS 581_ FIKIE 586_ EDTWQ 591_ KYYLE 596_ GVSNE 601_ MYTEY 606_ LSSAF 611_ VGLSF 616_ PTVCE 621_ LCFVK 626_ LKLLM 631_ IAIEY 636_ KSANR 641_ ESRIL 646_ INPGN 651_ HLKIQ 656_ EGTLG 661_ FFIAS 666_ DAKEV 671_ KRAFF 676_ YCKAC 681_ HDDIT 686_ DPKRI 691_ KKCGC 696_ KRPKM 701_ SIYKR 706_ MRRAC 711_ CFDCG 716_ RSERD 721_ CSCMS 726_ GRVRG 731_ NVDTL 736_ ERAFP 741_ LSSVS 746_ VNDCS 751_ TSFRA 756_ FEDEQ 761_ PSTLS 766_ PKKKQ 771_ RNGGM 776_ RNSPN 781_ TSPKL 786_ MRHDP 791_ LLIPG 796_ NDQID 801_ NMDSN 806_ VKKYD 811_ STGMF 816_ HWCAP 821_ KEIEK 826_ VILTR 831_ SEAAM 836_ TVLSG 841_ HVVVC 846_ IFGDV 851_ SSALI 856_ GLRNL 861_ VMPLR 866_ ASNFH 871_ YHELK 876_ HIVFV 881_ GSIEY 886_ LKREW 891_ ETLHN 896_ FPKVS 901_ ILPGT 906_ PLSRA 911_ DLRAV 916_ NINLC 921_ DMCVI 926_ LSANQ 931_ NNIDD 936_ TSLQD 941_ KECIL 946_ ASLNI 951_ KSMQF 956_ DDSIG 961_ VLQAN 966_ SQGFT 971_ PPGMD 976_ RSSPD 981_ NSPVH 986_ GMLRQ 991_ PSITT 996_ GVNIP 1001_ IITEL 1006_ VNDTN 1011_ VQFLD 1016_ QDDDD 1021_ DPDTE 1026_ LYLTQ 1031_ PFACG 1036_ TAFAV 1041_ SVLDS 1046_ LMSAT 1051_ YFNDN 1056_ ILTLI 1061_ RTLVT 1066_ GGATP 1071_ ELEAL 1076_ IAEEN 1081_ ALRGG 1086_ YSTPQ 1091_ TLANR 1096_ DRCRV 1101_ AQLAL 1106_ LDGPF 1111_ ADLGD 1116_ GGCYG 1121_ DLFCK 1126_ ALKTY 1131_ NMLCF 1136_ GIYRL 1141_ RDAHL 1146_ STPSQ 1151_ CTKRY 1156_ VITNP 1161_ PYEFE 1166_ LVPTD 1171_ LIFCL 1176_ MQFDH 1181_ NAGQS 1186_ RASLS 1191_ HSSHS 1196_ SQSSS 1201_ KKSSS 1206_ VHSIP 1211_ STANR 1216_ QNRPK 1221_ SRESR 1226_ DKQKY 1231_VQEER
1: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic transmission (PubMed:32958651)
2: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+)