Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF)
1_MAWAL 6_ KLPLA 11_ DEVIE 16_ SGLVQ 21_ DFDAS 26_ LSGIG 31_ QELGA 36_ GAYSM 41_ SDVLA 46_ LPIFK 51_ QEESS 56_ LPPDN 61_ ENKIL 66_ PFQYV 71_ LCAAT 76_ SPAVK 81_ LHDET 86_ LTYLN 91_ QGQSY 96_ EIRML 101_ DNRKL 106_ GELPE 111_ INGKL 116_ VKSIF 121_ RVVFH 126_ DRRLQ 131_ YTEHQ 136_ QLEGW 141_ RWNRP 146_ GDRIL 151_ DIDIP 156_ MSVGI 161_ IDPRA 166_ NPTQL 171_ NTVEF 176_ LWDPA 181_ KRTSV 186_ FIQVH 191_ CISTE 196_ FTMRK 201_ HGGEK 206_ GVPFR 211_ VQIDT 216_ FKENE 221_ NGEYT 226_ EHLHS 231_ ASCQI 236_ KVFKP 241_ KGADR 246_ KQKTD 251_ REKME 256_ KRTPH 261_ EKEKY 266_ QPSYE 271_ TTILT 276_ ECSPW 281_ PEITY 286_ VNNSP 291_ SPGFN 296_ SSHSS 301_ FSLGE 306_ GNGSP 311_ NHQPE 316_ PPPPV 321_ TDNLL 326_ PTTTP 331_ QEAQQ 336_ WLHRN 341_ RFSTF 346_ TRLFT 351_ NFSGA 356_ DLLKL 361_ TRDDV 366_ IQICG 371_ PADGI 376_ RLFNA 381_ LKGRM 386_ VRPRL 391_ TIYVC 396_ QESLQ 401_ LREQQ 406_ QQQQQ 411_ QQQKH 416_ EDGDS 421_ NGTFF 426_ VYHAI 431_ YLEEL 436_ TAVEL 441_ TEKIA 446_ QLFSI 451_ SPCQI 456_ SQIYK 461_ QGPTG 466_ IHVLI 471_ SDEMI 476_ QNFQE 481_ EACFI 486_ LDTMK 491_ AETND 496_SYHII
1: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter