A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
1_MKLNP 6_ QQAPL 11_ YGDCV 16_ VTVLL 21_ AEEDK 26_ AEDDV 31_ VFYLV 36_ FLGST 41_ LRHCT 46_ STRKV 51_ SSDTL 56_ ETIAP 61_ GHDCC 66_ ETVKV 71_ QLCAS 76_ KEGLP 81_ VFVVA 86_ EEDFH 91_ FVQDE 96_ AYDAA 101_ QFLAT 106_ SAGNQ 111_ QALNF 116_ TRFLD 121_ QSGPP 126_ SGDVN 131_ SLDKK 136_ LVLAF 141_ RHLKL 146_ PTEWN 151_ VLGTD 156_ QSLHD 161_ AGPRE 166_ TLMHF 171_ AVRLG 176_ LLRLT 181_ WFLLQ 186_ KPGGR 191_ GALSI 196_ HNQEG 201_ ATPVS 206_ LALER 211_ GYHKL 216_ HQLLT 221_ EENAG 226_ EPDSW 231_ SSLSY 236_ EIPYG 241_ DCSVR 246_ HHREL 251_ DIYTL 256_ TSESD 261_ SHHEH 266_ PFPGD 271_ GCTGP 276_ IFKLM 281_ NIQQQ 286_ LMKTN 291_ LKQMD 296_ SLMPL 301_ MMTAQ 306_ DPSSA 311_ PETDG 316_ QFLPC 321_ APEPT 326_ DPQRL 331_ SSSEE 336_ TESTQ 341_ CCPGS 346_ PVAQT 351_ ESPCD 356_ LSSIV 361_ EEENT 366_ DRSCR 371_ KKNKG 376_ VERKG 381_ EEVEP 386_ APIVD 391_ SGTVS 396_ DQDSC 401_ LQSLP 406_ DCGVK 411_ GTEGL 416_ SSCGN 421_ RNEET 426_ GTKSS 431_ GMPTD 436_ QESLS 441_ SGDAV 446_ LQRDL 451_ VMEPG 456_ TAQYS 461_ SGGEL 466_ GGIST 471_ TNVST 476_ PDTAG 481_ EMEHG 486_ LMNPD 491_ ATVWK 496_ NVLQG 501_ GESTK 506_ ERFEN 511_ SNIGT 516_ AGASD 521_ VHVTS 526_ KPVDK 531_ ISVPN 536_ CAPAA 541_ SSLDG 546_ NKPAE 551_ SSLAF 556_ SNEET 561_ STEKT 566_ AETET 571_ SRSRE 576_ ESADA 581_ PVDQN 586_ SVVIP 591_ AAAKD 596_ KISDG 601_ LEPYT 606_ LLAAG 611_ IGEAM 616_ SPSDL 621_ ALLGL 626_ EEDVM 631_ PHQNS 636_ ETNSS 641_ HAQSQ 646_ KGKSS 651_ PICST 656_ TGDDK 661_ LCADS 666_ ACQQN 671_ TVTSS 676_ GDLVA 681_ KLCDN 686_ IVSES 691_ ESTTA 696_ RQPSS 701_ QDPPD 706_ ASHCE 711_ DPQAH 716_ TVTSD 721_ PVRDT 726_ QERAD 731_ FCPFK 736_ VVDNK 741_ GQRKD 746_ VKLDK 751_ PLTNM 756_ LEVVS 761_ HPHPV 766_ VPKME 771_ KELVP 776_ DQAVI 781_ SDSTF 786_ SLANS 791_ PGSES 796_ VTKDD 801_ ALSFV 806_ PSQKE 811_ KGTAT 816_ PELHT 821_ ATDYR 826_ DGPDG 831_ NSNEP 836_ DTRPL 841_ EDRAV 846_ GLSTS 851_ STAAE 856_ LQHGM 861_ GNTSL 866_ TGLGG 871_ EHEGP 876_ APPAI 881_ PEALN 886_ IKGNT 891_ DSSLQ 896_ SVGKA 901_ TLALD 906_ SVLTE 911_ EGKLL 916_ VVSES 921_ SAAQE 926_ QDKDK 931_ AVTCS 936_ SIKEN 941_ ALSSG 946_ TLQEE 951_ QRTPP 956_ PGQDT 961_ QQFHE 966_ KSISA 971_ DCAKD 976_ KALQL 981_ SNSPG 986_ ASSAF 991_ LKAET 996_ EHNKE 1001_ VAPQV 1006_ SLLTQ 1011_ GGAAQ 1016_ SLVPP 1021_ GASLA 1026_ TESRQ 1031_ EALGA 1036_ EHNSS 1041_ ALLPC 1046_ LLPDG 1051_ SDGSD 1056_ ALNCS 1061_ QPSPL 1066_ DVGVK 1071_ NTQSQ 1076_ GKTSA 1081_ CEVSG 1086_ DVTVD 1091_ VTGVN 1096_ ALQGM 1101_ AEPRR 1106_ ENISH 1111_ NTQDI 1116_ LIPNV 1121_ LLSQE 1126_ KNAVL 1131_ GLPVA 1136_ LQDKA 1141_ VTDPQ 1146_ GVGTP 1151_ EMIPL 1156_ DWEKG 1161_ KLEGA 1166_ DHSCT 1171_ MGDAE 1176_ EAQID 1181_ DEAHP 1186_ VLLQP 1191_ VAKEL 1196_ PTDME 1201_ LSAHD 1206_ DGAPA 1211_ GVREV 1216_ MRAPP 1221_ SGRER 1226_ STPSL 1231_ PCMVS 1236_ AQDAP 1241_ LPKGA 1246_ DLIEE 1251_ AASRI 1256_ VDAVI 1261_ EQVKA 1266_ AGALL 1271_ TEGEA 1276_ CHMSL 1281_ SSPEL 1286_ GPLTK 1291_ GLESA 1296_ FTEKV 1301_ STFPP 1306_ GESLP 1311_ MGSTP 1316_ EEATG 1321_ SLAGC 1326_ FAGRE 1331_ EPEKI 1336_ ILPVQ 1341_ GPEPA 1346_ AEMPD 1351_ VKAED 1356_ EVDFR 1361_ ASSIS 1366_ EEVAV 1371_ GSIAA 1376_ TLKMK 1381_ QGPMT 1386_ QAINR 1391_ ENWCT 1396_ IEPCP 1401_ DAASL 1406_ LASKQ 1411_ SPECE 1416_ NFLDV 1421_ GLGRE 1426_ CTSKQ 1431_ GVLKR 1436_ ESGSD 1441_ SDLFH 1446_ SPSDD 1451_ MDSII 1456_ FPKPE 1461_ EEHLA 1466_ CDITG 1471_ SSSST 1476_ DDTAS 1481_ LDRHS 1486_ SHGSD 1491_ VSLSQ 1496_ ILKPN 1501_ RSRDR 1506_ QSLDG 1511_ FYSHG 1516_ MGAEG 1521_ RESES 1526_ EPADP 1531_ GDVEE 1536_ EEMDS 1541_ ITEVP 1546_ ANCSV 1551_ LRSSM 1556_ RSLSP 1561_ FRRHS 1566_ WGPGK 1571_ NAASD 1576_ AEMNH 1581_ RSSMR 1586_ VLGDV 1591_ VRRPP 1596_ IHRRS 1601_ FSLEG 1606_ LTGGA 1611_ GVGNK 1616_ PSSSL 1621_ EVSSA 1626_ NAEEL 1631_ RHPFS 1636_ GEERV 1641_ DSLVS 1646_ LSEED 1651_ LESDQ 1656_ REHRM 1661_ FDQQI 1666_ CHRSK 1671_ QQGFN 1676_ YCTSA 1681_ ISSPL 1686_ TKSIS 1691_ LMTIS 1696_ HPGLD 1701_ NSRPF 1706_ HSTFH 1711_ NTSAN 1716_ LTESI 1721_ TEENY 1726_ NFLPH 1731_ SPSKK 1736_ DSEWK 1741_ SGTKV 1746_ SRTFS 1751_ YIKNK 1756_ MSSSK 1761_ KSKEK 1766_ EKEKD 1771_ KIKEK 1776_ EKDSK 1781_ DKEKD 1786_ KKTVN 1791_ GHTFS 1796_ SIPVV 1801_ GPISC 1806_ SQCMK 1811_ PFTNK 1816_ DAYTC 1821_ ANCSA 1826_ FVHKG 1831_ CRESL 1836_ ASCAK 1841_ VKMKQ 1846_ PKGSL 1851_ QAHDT 1856_ SSLPT 1861_ VIMRN 1866_ KPSQP 1871_ KERPR 1876_ SAVLL 1881_ VDETA 1886_ TTPIF 1891_ ANRRS 1896_ QQSVS 1901_ LSKSV 1906_ SIQNI 1911_ TGVGN 1916_ DENMS 1921_ NTWKF 1926_ LSHST 1931_ DSLNK 1936_ ISKVN 1941_ ESTES 1946_ LTDEG 1951_ VGTDM 1956_ NEGQL 1961_ LGDFE 1966_ IESKQ 1971_ LEAES 1976_ WSRII 1981_ DSKFL 1986_ KQQKK 1991_ DVVKR 1996_ QEVIY 2001_ ELMQT 2006_ EFHHV 2011_ RTLKI 2016_ MSGVY 2021_ SQGMM 2026_ ADLLF 2031_ EQQMV 2036_ EKLFP 2041_ CLDEL 2046_ ISIHS 2051_ QFFQR 2056_ ILERK 2061_ KESLV 2066_ DKSEK 2071_ NFLIK 2076_ RIGDV 2081_ LVNQF 2086_ SGENA 2091_ ERLKK 2096_ TYGKF 2101_ CGQHN 2106_ QSVNY 2111_ FKDLY 2116_ AKDKR 2121_ FQAFV 2126_ KKKMS 2131_ SSVVR 2136_ RLGIP 2141_ ECILL 2146_ VTQRI 2151_ TKYPV 2156_ LFQRI 2161_ LQCTK 2166_ DNEVE 2171_ QEDLA 2176_ QSLSL 2181_ VKDVI 2186_ GAVDS 2191_ KVASY 2196_ EKKVR 2201_ LNEIY 2206_ TKTDS 2211_ KSIMR 2216_ MKSGQ 2221_ MFAKE 2226_ DLKRK 2231_ KLVRD 2236_ GSVFL 2241_ KNAAG 2246_ RLKEV 2251_ QAVLL 2256_ TDILV 2261_ FLQEK 2266_ DQKYI 2271_ FASLD 2276_ QKSTV 2281_ ISLKK 2286_ LIVRE 2291_ VAHEE 2296_ KGLFL 2301_ ISMGM 2306_ TDPEM 2311_ VEVHA 2316_ SSKEE 2321_ RNSWI 2326_ QIIQD 2331_ TINTL 2336_ NRDED 2341_ EGIPS 2346_ ENEEE 2351_ KKMLD 2356_ TRARE 2361_ LKEQL 2366_ HQKDQ 2371_ KILLL 2376_ LEEKE 2381_ MIFRD 2386_ MAECS 2391_ TPLPE 2396_ DCSPT 2401_ HSPRV 2406_ LFRSN 2411_ TEEAL 2416_ KGGPL 2421_ MKSAI 2426_ NEVEI 2431_ LQGLV 2436_ SGNLG 2441_ GTLGP 2446_ TVSSP 2451_ IEQDV 2456_ VGPVS 2461_ LPRRA 2466_ ETFGG 2471_ FDSHQ 2476_ MNASK 2481_ GGEKE 2486_ EGDDG 2491_ QDLRR 2496_ TESDS 2501_ GLKKG 2506_ GNANL 2511_ VFMLK 2516_ RNSEQ 2521_ VVQSV 2526_ VHLYE 2531_ LLSAL 2536_ QGVVL 2541_ QQDSY 2546_ IEDQK 2551_ LVLSE 2556_ RALTR 2561_ SLSRP 2566_ SSLIE 2571_ QEKQR 2576_ SLEKQ 2581_ RQDLA 2586_ NLQKQ 2591_ QAQYL 2596_ EEKRR 2601_ REREW 2606_ EARER 2611_ ELRER 2616_ EALLA 2621_ QREEE 2626_ VQQGQ 2631_ QDLEK 2636_ EREEL 2641_ QQKKG 2646_ TYQYD 2651_ LERLR 2656_ AAQKQ 2661_ LEREQ 2666_ EQLRR 2671_ EAERL 2676_ SQRQT 2681_ ERDLC 2686_ QVSHP 2691_ HTKLM 2696_ RIPSF 2701_ FPSPE 2706_ EPPSP 2711_ SAPSI 2716_ AKSGS 2721_ LDSEL 2726_ SVSPK 2731_ RNSIS 2736_ RTHKD 2741_ KGPFH 2746_ ILSST 2751_ SQTNK 2756_ GPEGQ 2761_ SQAPA 2766_ STSAS 2771_ TRLFG 2776_ LTKPK 2781_ EKKEK 2786_ KKKNK 2791_ TSRSQ 2796_ PGDGP 2801_ ASEVS 2806_AEGEE
1: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity)