Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
1_MPVRR 6_ GHVAP 11_ QNTFL 16_ DTIIR 21_ KFEGQ 26_ SRKFI 31_ IANAR 36_ VENCA 41_ VIYCN 46_ DGFCE 51_ LCGYS 56_ RAEVM 61_ QRPCT 66_ CDFLH 71_ GPRTQ 76_ RRAAA 81_ QIAQA 86_ LLGAE 91_ ERKVE 96_ IAFYR 101_ KDGSC 106_ FLCLV 111_ DVVPV 116_ KNEDG 121_ AVIMF 126_ ILNFE 131_ VVMEK 136_ DMVGS 141_ PAHDT 146_ NHRGP 151_ PTSWL 156_ APGRA 161_ KTFRL 166_ KLPAL 171_ LALTA 176_ RESSV 181_ RSGGA 186_ GGAGA 191_ PGAVV 196_ VDVDL 201_ TPAAP 206_ SSESL 211_ ALDEV 216_ TAMDN 221_ HVAGL 226_ GPAEE 231_ RRALV 236_ GPGSP 241_ PRSAP 246_ GQLPS 251_ PRAHS 256_ LNPDA 261_ SGSSC 266_ SLART 271_ RSRES 276_ CASVR 281_ RASSA 286_ DDIEA 291_ MRAGV 296_ LPPPP 301_ RHAST 306_ GAMHP 311_ LRSGL 316_ LNSTS 321_ DSDLV 326_ RYRTI 331_ SKIPQ 336_ ITLNF 341_ VDLKG 346_ DPFLA 351_ SPTSD 356_ REIIA 361_ PKIKE 366_ RTHNV 371_ TEKVT 376_ QVLSL 381_ GADVL 386_ PEYKL 391_ QAPRI 396_ HRWTI 401_ LHYSP 406_ FKAVW 411_ DWLIL 416_ LLVIY 421_ TAVFT 426_ PYSAA 431_ FLLKE 436_ TEEGP 441_ PATEC 446_ GYACQ 451_ PLAVV 456_ DLIVD 461_ IMFIV 466_ DILIN 471_ FRTTY 476_ VNANE 481_ EVVSH 486_ PGRIA 491_ VHYFK 496_ GWFLI 501_ DMVAA 506_ IPFDL 511_ LIFGS 516_ GSEEL 521_ IGLLK 526_ TARLL 531_ RLVRV 536_ ARKLD 541_ RYSEY 546_ GAAVL 551_ FLLMC 556_ TFALI 561_ AHWLA 566_ CIWYA 571_ IGNME 576_ QPHMD 581_ SRIGW 586_ LHNLG 591_ DQIGK 596_ PYNSS 601_ GLGGP 606_ SIKDK 611_ YVTAL 616_ YFTFS 621_ SLTSV 626_ GFGNV 631_ SPNTN 636_ SEKIF 641_ SICVM 646_ LIGSL 651_ MYASI 656_ FGNVS 661_ AIIQR 666_ LYSGT 671_ ARYHT 676_ QMLRV 681_ REFIR 686_ FHQIP 691_ NPLRQ 696_ RLEEY 701_ FQHAW 706_ SYTNG 711_ IDMNA 716_ VLKGF 721_ PECLQ 726_ ADICL 731_ HLNRS 736_ LLQHC 741_ KPFRG 746_ ATKGC 751_ LRALA 756_ MKFKT 761_ THAPP 766_ GDTLV 771_ HAGDL 776_ LTALY 781_ FISRG 786_ SIEIL 791_ RGDVV 796_ VAILG 801_ KNDIF 806_ GEPLN 811_ LYARP 816_ GKSNG 821_ DVRAL 826_ TYCDL 831_ HKIHR 836_ DDLLE 841_ VLDMY 846_ PEFSD 851_ HFWSS 856_ LEITF 861_ NLRDT 866_ NMIPG 871_ SPGST 876_ ELEGG 881_ FSRQR 886_ KRKLS 891_ FRRRT 896_ DKDTE 901_ QPGEV 906_ SALGP 911_ GRAGA 916_ GPSSR 921_ GRPGG 926_ PWGES 931_ PSSGP 936_ SSPES 941_ SEDEG 946_ PGRSS 951_ SPLRL 956_ VPFSS 961_ PRPPG 966_ EPPGG 971_ EPLME 976_ DCEKS 981_ SDTCN 986_ PLSGA 991_ FSGVS 996_ NIFSF 1001_ WGDSR 1006_ GRQYQ 1011_ ELPRC 1016_ PAPTP 1021_ SLLNI 1026_ PLSSP 1031_ GRRPR 1036_ GDVES 1041_ RLDAL 1046_ QRQLN 1051_ RLETR 1056_ LSADM 1061_ ATVLQ 1066_ LLQRQ 1071_ MTLVP 1076_ PAYSA 1081_ VTTPG 1086_ PGPTS 1091_ TSPLL 1096_ PVSPL 1101_ PTLTL 1106_ DSLSQ 1111_ VSQFM 1116_ ACEEL 1121_ PPGAP 1126_ ELPQE 1131_ GPTRR 1136_ LSLPG 1141_ QLGAL 1146_ TSQPL 1151_HRHGS
1: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439)
2: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation
3: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation