SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)
1_MMMMA 6_ LSKTF 11_ GQKPV 16_ KFQLE 21_ DDGEF 26_ YMIGS 31_ EVGNY 36_ LRMFR 41_ GSLYK 46_ RYPSL 51_ WRRLA 56_ TVEER 61_ KKIVA 66_ SSHGK 71_ KTKPN 76_ TKDHG 81_ YTTLA 86_ TSVTL 91_ LKASE 96_ VEEIL 101_ DGNDE 106_ KYKAV 111_ SISTE 116_ PPTYL 121_ REQKA 126_ KRNSQ 131_ WVPTL 136_ PNSSH 141_ HLDAV 146_ PCSTT 151_ INRNR 156_ MGRDK 161_ KRTFP 166_ LCFDD 171_ HDPAV 176_ IHENA 181_ SQPEV 186_ LVPIR 191_ LDMEI 196_ DGQKL 201_ RDAFT 206_ WNMNE 211_ KLMTP 216_ EMFSE 221_ ILCDD 226_ LDLNP 231_ LTFVP 236_ AIASA 241_ IRQQI 246_ ESYPT 251_ DSILE 256_ DQSDQ 261_ RVIIK 266_ LNIHV 271_ GNISL 276_ VDQFE 281_ WDMSE 286_ KENSP 291_ EKFAL 296_ KLCSE 301_ LGLGG 306_ EFVTT 311_ IAYSI 316_ RGQLS 321_ WHQKT 326_ YAFSE 331_ NPLPT 336_ VEIAI 341_ RNTGD 346_ ADQWC 351_ PLLET 356_ LTDAE 361_ MEKKI 366_ RDQDR 371_ NTRRM 376_RRLAN
1: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1