Cell division cycle protein 20 homolog (p55CDC)
1_MAQFA 6_ FESDL 11_ HSLLQ 16_ LDAPI 21_ PNAPP 26_ ARWQR 31_ KAKEA 36_ AGPAP 41_ SPMRA 46_ ANRSH 51_ SAGRT 56_ PGRTP 61_ GKSSS 66_ KVQTT 71_ PSKPG 76_ GDRYI 81_ PHRSA 86_ AQMEV 91_ ASFLL 96_ SKENQ 101_ PENSQ 106_ TPTKK 111_ EHQKA 116_ WALNL 121_ NGFDV 126_ EEAKI 131_ LRLSG 136_ KPQNA 141_ PEGYQ 146_ NRLKV 151_ LYSQK 156_ ATPGS 161_ SRKTC 166_ RYIPS 171_ LPDRI 176_ LDAPE 181_ IRNDY 186_ YLNLV 191_ DWSSG 196_ NVLAV 201_ ALDNS 206_ VYLWS 211_ ASSGD 216_ ILQLL 221_ QMEQP 226_ GEYIS 231_ SVAWI 236_ KEGNY 241_ LAVGT 246_ SSAEV 251_ QLWDV 256_ QQQKR 261_ LRNMT 266_ SHSAR 271_ VGSLS 276_ WNSYI 281_ LSSGS 286_ RSGHI 291_ HHHDV 296_ RVAEH 301_ HVATL 306_ SGHSQ 311_ EVCGL 316_ RWAPD 321_ GRHLA 326_ SGGND 331_ NLVNV 336_ WPSAP 341_ GEGGW 346_ VPLQT 351_ FTQHQ 356_ GAVKA 361_ VAWCP 366_ WQSNV 371_ LATGG 376_ GTSDR 381_ HIRIW 386_ NVCSG 391_ ACLSA 396_ VDAHS 401_ QVCSI 406_ LWSPH 411_ YKELI 416_ SGHGF 421_ AQNQL 426_ VIWKY 431_ PTMAK 436_ VAELK 441_ GHTSR 446_ VLSLT 451_ MSPDG 456_ ATVAS 461_ AAADE 466_ TLRLW 471_ RCFEL 476_ DPARR 481_ REREK 486_ ASAAK 491_SSLIH
1: Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity)