Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
1_MRDRT 6_ HELRQ 11_ GDDSS 16_ DEEDK 21_ ERVAL 26_ VVHPG 31_ TARLG 36_ SPDEE 41_ FFHKV 46_ RTIRQ 51_ TIVKL 56_ GNKVQ 61_ ELEKQ 66_ QVTIL 71_ ATPLP 76_ EESMK 81_ QELQN 86_ LRDEI 91_ KQLGR 96_ EIRLQ 101_ LKAIE 106_ PQKEE 111_ ADENY 116_ NSVNT 121_ RMRKT 126_ QHGVL 131_ SQQFV 136_ ELINK 141_ CNSMQ 146_ SEYRE 151_ KNVER 156_ IRRQL 161_ KITNA 166_ GMVSD 171_ EELEQ 176_ MLDSG 181_ QSEVF 186_ VSNIL 191_ KDTQV 196_ TRQAL 201_ NEISA 206_ RHSEI 211_ QQLER 216_ SIREL 221_ HDIFT 226_ FLATE 231_ VEMQG 236_ EMINR 241_ IEKNI 246_ LSSAD 251_ YVERG 256_ QEHVK 261_ TALEN 266_ QKKAR 271_ KKKVL 276_ IAICV 281_ SITVV 286_ LLAVI 291_IGVTV
1: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422)