G-rich sequence factor 1 (GRSF-1)
1_MAGTR 6_ WVLGA 11_ LLRGC 16_ GCNCS 21_ SCRRT 26_ GAACL 31_ PFYSA 36_ AGSIP 41_ SGVSG 46_ RRRLL 51_ LLLGA 56_ AAAAA 61_ SQTRG 66_ LQTGP 71_ VPPGR 76_ LAGPP 81_ AVATS 86_ AAAAA 91_ AASYS 96_ ALRAS 101_ LLPQS 106_ LAAAA 111_ AVPTR 116_ SYSQE 121_ SKTTY 126_ LEDLP 131_ PPPEY 136_ ELAPS 141_ KLEEE 146_ VDDVF 151_ LIRAQ 156_ GLPWS 161_ CTMED 166_ VLNFF 171_ SDCRI 176_ RNGEN 181_ GIHFL 186_ LNRDG 191_ KRRGD 196_ ALIEM 201_ ESEQD 206_ VQKAL 211_ EKHRM 216_ YMGQR 221_ YVEVY 226_ EINNE 231_ DVDAL 236_ MKSLQ 241_ VKSSP 246_ VVNDG 251_ VVRLR 256_ GLPYS 261_ CNEKD 266_ IVDFF 271_ AGLNI 276_ VDITF 281_ VMDYR 286_ GRRKT 291_ GEAYV 296_ QFEEP 301_ EMANQ 306_ ALLKH 311_ REEIG 316_ NRYIE 321_ IFPSR 326_ RNEVR 331_ THVGS 336_ YKGKK 341_ IASFP 346_ TAKYI 351_ TEPEM 356_ VFEEH 361_ EVNED 366_ IQPMT 371_ AFESE 376_ KEIEL 381_ PKEVP 386_ EKLPE 391_ AADFG 396_ TTSSL 401_ HFVHM 406_ RGLPF 411_ QANAQ 416_ DIINF 421_ FAPLK 426_ PVRIT 431_ MEYSS 436_ SGKAT 441_ GEADV 446_ HFETH 451_ EDAVA 456_ AMLKD 461_ RSHVH 466_ HRYIE 471_LFLNS
1: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381)