Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
1_MACLH 6_ ETRTP 11_ SPSFG 16_ GFVST 21_ LSEAS 26_ MRKLD 31_ PDTSD 36_ CTPEK 41_ DLTPT 46_ HVLQL 51_ HEQDA 56_ GGPGG 61_ AAGSP 66_ ESRAS 71_ RVRAD 76_ EVRLQ 81_ CQSGS 86_ GFLEG 91_ LFGCL 96_ RPVWT 101_ MIGKA 106_ YSTEH 111_ KQQQE 116_ DLWEV 121_ PFEEI 126_ LDLQW 131_ VGSGA 136_ QGAVF 141_ LGRFH 146_ GEEVA 151_ VKKVR 156_ DLKET 161_ DIKHL 166_ RKLKH 171_ PNIIT 176_ FKGVC 181_ TQAPC 186_ YCILM 191_ EFCAQ 196_ GQLYE 201_ VLRAG 206_ RPVTP 211_ SLLVD 216_ WSMGI 221_ AGGMN 226_ YLHLH 231_ KIIHR 236_ DLKSP 241_ NMLIT 246_ YDDVV 251_ KISDF 256_ GTSKE 261_ LSDKS 266_ TKMSF 271_ AGTVA 276_ WMAPE 281_ VIRNE 286_ PVSEK 291_ VDIWS 296_ FGVVL 301_ WELLT 306_ GEIPY 311_ KDVDS 316_ SAIIW 321_ GVGSN 326_ SLHLP 331_ VPSSC 336_ PDGFK 341_ ILLRQ 346_ CWNSK 351_ PRNRP 356_ SFRQI 361_ LLHLD 366_ IASAD 371_ VLSTP 376_ QETYF 381_ KSQAE 386_ WREEV 391_ KLHFE 396_ KIKSE 401_ GTCLH 406_ RLEEE 411_ LVMRR 416_ REELR 421_ HALDI 426_ REHYE 431_ RKLER 436_ ANNLY 441_ MELNA 446_ LMLQL 451_ ELKER 456_ ELLRR 461_ EQALE 466_ RRCPG 471_ LLKPH 476_ PSRGL 481_ LHGNT 486_ MEKLI 491_ KKRNV 496_ PQKLS 501_ PHSKR 506_ PDILK 511_ TESLL 516_ PKLDA 521_ ALSGV 526_ GLPGC 531_ PKGPP 536_ SPGRS 541_ RRGKT 546_ RHRKA 551_ SAKGS 556_ CGDLP 561_ GLRTA 566_ VPPHE 571_ PGGPG 576_ SPGGL 581_ GGGPS 586_ AWEAC 591_ PPALR 596_ GLHHD 601_ LLLRK 606_ MSSSS 611_ PDLLS 616_ AALGS 621_ RGRGA 626_ TGGAG 631_ DPGSP 636_ PPARG 641_ DTPPS 646_ EGSAP 651_ GSTSP 656_ DSPGG 661_ AKGEP 666_ PPPVG 671_ PGEGV 676_ GLLGT 681_ GREGT 686_ SGRGG 691_ SRAGS 696_ QHLTP 701_ AALLY 706_ RAAVT 711_ RSQKR 716_ GISSE 721_ EEEGE 726_ VDSEV 731_ ELTSS 736_ QRWPQ 741_ SLNMR 746_ QSLST 751_ FSSEN 756_ PSDGE 761_ EGTAS 766_ EPSPS 771_ GTPEV 776_ GSTNT 781_ DERPD 786_ ERSDD 791_ MCSQG 796_ SEIPL 801_ DPPPS 806_ EVIPG 811_ PEPSS 816_ LPIPH 821_ QELLR 826_ ERGPP 831_ NSEDS 836_ DCDST 841_ ELDNS 846_ NSVDA 851_LRPPA
1: Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway