Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
1_MKMWL 6_ LVSHL 11_ VIISI 16_ TTCLA 21_ EFTWY 26_ RRYGH 31_ GVSEE 36_ DKGFG 41_ PIFEE 46_ QPINT 51_ IYPEE 56_ SLEGK 61_ VSLNC 66_ RARAS 71_ PFPVY 76_ KWRMN 81_ NGDVD 86_ LTSDR 91_ YSMVG 96_ GNLVI 101_ NNPDK 106_ QKDAG 111_ IYYCL 116_ ASNNY 121_ GMVRS 126_ TEATL 131_ SFGYL 136_ DPFPP 141_ EERPE 146_ VRVKE 151_ GKGMV 156_ LLCDP 161_ PYHFP 166_ DDLSY 171_ RWLLN 176_ EFPVF 181_ ITMDK 186_ RRFVS 191_ QTNGN 196_ LYIAN 201_ VEASD 206_ KGNYS 211_ CFVSS 216_ PSITK 221_ SVFSK 226_ FIPLI 231_ PIPER 236_ TTKPY 241_ PADIV 246_ VQFKD 251_ VYALM 256_ GQNVT 261_ LECFA 266_ LGNPV 271_ PDIRW 276_ RKVLE 281_ PMPST 286_ AEIST 291_ SGAVL 296_ KIFNI 301_ QLEDE 306_ GIYEC 311_ EAENI 316_ RGKDK 321_ HQARI 326_ YVQAF 331_ PEWVE 336_ HINDT 341_ EVDIG 346_ SDLYW 351_ PCVAT 356_ GKPIP 361_ TIRWL 366_ KNGYA 371_ YHKGE 376_ LRLYD 381_ VTFEN 386_ AGMYQ 391_ CIAEN 396_ TYGAI 401_ YANAE 406_ LKILA 411_ LAPTF 416_ EMNPM 421_ KKKIL 426_ AAKGG 431_ RVIIE 436_ CKPKA 441_ APKPK 446_ FSWSK 451_ GTEWL 456_ VNSSR 461_ ILIWE 466_ DGSLE 471_ INNIT 476_ RNDGG 481_ IYTCF 486_ AENNR 491_ GKANS 496_ TGTLV 501_ ITDPT 506_ RIILA 511_ PINAD 516_ ITVGE 521_ NATMQ 526_ CAASF 531_ DPALD 536_ LTFVW 541_ SFNGY 546_ VIDFN 551_ KENIH 556_ YQRNF 561_ MLDSN 566_ GELLI 571_ RNAQL 576_ KHAGR 581_ YTCTA 586_ QTIVD 591_ NSSAS 596_ ADLVV 601_ RGPPG 606_ PPGGL 611_ RIEDI 616_ RATSV 621_ ALTWS 626_ RGSDN 631_ HSPIS 636_ KYTIQ 641_ TKTIL 646_ SDDWK 651_ DAKTD 656_ PPIIE 661_ GNMEA 666_ ARAVD 671_ LIPWM 676_ EYEFR 681_ VVATN 686_ TLGRG 691_ EPSIP 696_ SNRIK 701_ TDGAA 706_ PNVAP 711_ SDVGG 716_ GGGRN 721_ RELTI 726_ TWAPL 731_ SREYH 736_ YGNNF 741_ GYIVA 746_ FKPFD 751_ GEEWK 756_ KVTVT 761_ NPDTG 766_ RYVHK 771_ DETMS 776_ PSTAF 781_ QVKVK 786_ AFNNK 791_ GDGPY 796_ SLVAV 801_ INSAQ 806_ DAPSE 811_ APTEV 816_ GVKVL 821_ SSSEI 826_ SVHWE 831_ HVLEK 836_ IVESY 841_ QIRYW 846_ AAHDK 851_ EEAAN 856_ RVQVT 861_ SQEYS 866_ ARLEN 871_ LLPDT 876_ QYFIE 881_ VGACN 886_ SAGCG 891_ PPSDM 896_ IEAFT 901_ KKAPP 906_ SQPPR 911_ IISSV 916_ RSGSR 921_ YIITW 926_ DHVVA 931_ LSNES 936_ TVTGY 941_ KVLYR 946_ PDGQH 951_ DGKLY 956_ STHKH 961_ SIEVP 966_ IPRDG 971_ EYVVE 976_ VRAHS 981_ DGGDG 986_ VVSQV 991_ KISGA 996_ PTLSP 1001_ SLLGL 1006_ LLPAF 1011_GILVY
1: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity)