Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
1_MGPAP 6_ LPLLL 11_ GLFLP 16_ ALWRR 21_ AITEA 26_ REEAK 31_ PYPLF 36_ PGPFP 41_ GSLQT 46_ DHTPL 51_ LSLPH 56_ ASGYQ 61_ PALMF 66_ SPTQP 71_ GRPHT 76_ GNVAI 81_ PQVTS 86_ VESKP 91_ LPPLA 96_ FKHTV 101_ GHIIL 106_ SEHKG 111_ VKFNC 116_ SISVP 121_ NIYQD 126_ TTISW 131_ WKDGK 136_ ELLGA 141_ HHAIT 146_ QFYPD 151_ DEVTA 156_ IIASF 161_ SITSV 166_ QRSDN 171_ GSYIC 176_ KMKIN 181_ NEEIV 186_ SDPIY 191_ IEVQG 196_ LPHFT 201_ KQPES 206_ MNVTR 211_ NTAFN 216_ LTCQA 221_ VGPPE 226_ PVNIF 231_ WVQNS 236_ SRVNE 241_ QPEKS 246_ PSVLT 251_ VPGLT 256_ EMAVF 261_ SCEAH 266_ NDKGL 271_ TVSKG 276_ VQINI 281_ KAIPS 286_ PPTEV 291_ SIRNS 296_ TAHSI 301_ LISWV 306_ PGFDG 311_ YSPFR 316_ NCSIQ 321_ VKEAD 326_ PLSNG 331_ SVMIF 336_ NTSAL 341_ PHLYQ 346_ IKQLQ 351_ ALANY 356_ SIGVS 361_ CMNEI 366_ GWSAV 371_ SPWIL 376_ ASTTE 381_ GAPSV 386_ APLNV 391_ TVFLN 396_ ESSDN 401_ VDIRW 406_ MKPPT 411_ KQQDG 416_ ELVGY 421_ RISHV 426_ WQSAG 431_ ISKEL 436_ LEEVG 441_ QNGSR 446_ ARISV 451_ QVHNA 456_ TCTVR 461_ IAAVT 466_ RGGVG 471_ PFSDP 476_ VKIFI 481_ PAHGW 486_ VDYAP 491_ SSTPA 496_ PGNAD 501_ PVLII 506_ FGCFC 511_ GFILI 516_ GLILY 521_ ISLAI 526_ RKRVQ 531_ ETKFG 536_ NAFTE 541_ EDSEL 546_ VVNYI 551_ AKKSF 556_ CRRAI 561_ ELTLH 566_ SLGVS 571_ EELQN 576_ KLEDV 581_ VIDRN 586_ LLILG 591_ KILGE 596_ GEFGS 601_ VMEGN 606_ LKQED 611_ GTSLK 616_ VAVKT 621_ MKLDN 626_ SSQRE 631_ IEEFL 636_ SEAAC 641_ MKDFS 646_ HPNVI 651_ RLLGV 656_ CIEMS 661_ SQGIP 666_ KPMVI 671_ LPFMK 676_ YGDLH 681_ TYLLY 686_ SRLET 691_ GPKHI 696_ PLQTL 701_ LKFMV 706_ DIALG 711_ MEYLS 716_ NRNFL 721_ HRDLA 726_ ARNCM 731_ LRDDM 736_ TVCVA 741_ DFGLS 746_ KKIYS 751_ GDYYR 756_ QGRIA 761_ KMPVK 766_ WIAIE 771_ SLADR 776_ VYTSK 781_ SDVWA 786_ FGVTM 791_ WEIAT 796_ RGMTP 801_ YPGVQ 806_ NHEMY 811_ DYLLH 816_ GHRLK 821_ QPEDC 826_ LDELY 831_ EIMYS 836_ CWRTD 841_ PLDRP 846_ TFSVL 851_ RLQLE 856_ KLLES 861_ LPDVR 866_ NQADV 871_ IYVNT 876_ QLLES 881_ SEGLA 886_ QGSTL 891_ APLDL 896_ NIDPD 901_ SIIAS 906_ CTPRA 911_ AISVV 916_ TAEVH 921_ DSKPH 926_ EGRYI 931_ LNGGS 936_ EEWED 941_ LTSAP 946_ SAAVT 951_ AEKNS 956_ VLPGE 961_ RLVRN 966_ GVSWS 971_ HSSML 976_ PLGSS 981_ LPDEL 986_ LFADD 991_SSEGS
1: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3