Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2)
1_MAFAL 6_ LRPVG 11_ AHVLY 16_ PDVRL 21_ LSEDE 26_ ENRSE 31_ SDASD 36_ QSFGC 41_ CEGPE 46_ AARRG 51_ PGPGG 56_ GRRAG 61_ GGGGA 66_ GPVVV 71_ VRQRQ 76_ AANAR 81_ ERDRT 86_ QSVNT 91_ AFTAL 96_ RTLIP 101_ TEPVD 106_ RKLSK 111_ IETVR 116_ LASSY 121_ IAHLA 126_ NVLLL 131_ GDSAD 136_ DGQPC 141_ FRAAG 146_ SAKGA 151_ VPAAA 156_ DGGRQ 161_ PRSIC 166_ TFCLS 171_ NQRKG 176_ GGRRD 181_ LGGSC 186_ LKVRG 191_VAPLR
1: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes