Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)
1_METIL 6_ EQQRR 11_ YHEEK 16_ ERLMD 21_ VMAKE 26_ MLTKK 31_ STLRD 36_ QINSD 41_ HRTRA 46_ MQDRY 51_ MEVSG 56_ NLRDL 61_ YDDKD 66_ GLRKE 71_ ELNAI 76_ SGPNE 81_ FAEFY 86_ NRLKQ 91_ IKEFH 96_ RKHPN 101_ EICVP 106_ MSVEF 111_ EELLK 116_ ARENP 121_ SEEAQ 126_ NLVEF 131_ TDEEG 136_ YGRYL 141_ DLHDC 146_ YLKYI 151_ NLKAS 156_ EKLDY 161_ ITYLS 166_ IFDQL 171_ FDIPK 176_ ERKNA 181_ EYKRY 186_ LEMLL 191_ EYLQD 196_ YTDRV 201_ KPLQD 206_ QNELF 211_ GKIQA 216_ EFEKK 221_ WENGT 226_ FPGWP 231_ KETSS 236_ ALTHA 241_ GAHLD 246_ LSAFS 251_ SWEEL 256_ ASLGL 261_ DRLKS 266_ ALLAL 271_ GLKCG 276_ GTLEE 281_ RAQRL 286_ FSTKG 291_ KSLES 296_ LDTSL 301_ FAKNP 306_ KSKGT 311_ KRDTE 316_ RNKDI 321_ AFLEA 326_ QIYEY 331_ VEILG 336_ EQRHL 341_ THENV 346_ QRKQA 351_ RTGEE 356_ REEEE 361_ EEQIS 366_ ESESE 371_ DEENE 376_ IIYNP 381_ KNLPL 386_ GWDGK 391_ PIPYW 396_ LYKLH 401_ GLNIN 406_ YNCEI 411_ CGNYT 416_ YRGPK 421_ AFQRH 426_ FAEWR 431_ HAHGM 436_ RCLGI 441_ PNTAH 446_ FANVT 451_ QIEDA 456_ VSLWA 461_ KLKLQ 466_ KASER 471_ WQPDT 476_ EEEYE 481_ DSSGN 486_ VVNKK 491_ TYEDL 496_KRQGL
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277)