Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
1_MGRVG 6_ YWTLL 11_ VLPAL 16_ LVWRG 21_ PAPSA 26_ AAEKG 31_ PPALN 36_ IAVML 41_ GHSHD 46_ VTERE 51_ LRTLW 56_ GPEQA 61_ AGLPL 66_ DVNVV 71_ ALLMN 76_ RTDPK 81_ SLITH 86_ VCDLM 91_ SGARI 96_ HGLVF 101_ GDDTD 106_ QEAVA 111_ QMLDF 116_ ISSHT 121_ FVPIL 126_ GIHGG 131_ ASMIM 136_ ADKDP 141_ TSTFF 146_ QFGAS 151_ IQQQA 156_ TVMLK 161_ IMQDY 166_ DWHVF 171_ SLVTT 176_ IFPGY 181_ REFIS 186_ FVKTT 191_ VDNSF 196_ VGWDM 201_ QNVIT 206_ LDTSF 211_ EDAKT 216_ QVQLK 221_ KIHSS 226_ VILLY 231_ CSKDE 236_ AVLIL 241_ SEARS 246_ LGLTG 251_ YDFFW 256_ IVPSL 261_ VSGNT 266_ ELIPK 271_ EFPSG 276_ LISVS 281_ YDDWD 286_ YSLEA 291_ RVRDG 296_ IGILT 301_ TAASS 306_ MLEKF 311_ SYIPE 316_ AKASC 321_ YGQME 326_ RPEVP 331_ MHTLH 336_ PFMVN 341_ VTWDG 346_ KDLSF 351_ TEEGY 356_ QVHPR 361_ LVVIV 366_ LNKDR 371_ EWEKV 376_ GKWEN 381_ HTLSL 386_ RHAVW 391_ PRYKS 396_ FSDCE 401_ PDDNH 406_ LSIVT 411_ LEEAP 416_ FVIVE 421_ DIDPL 426_ TETCV 431_ RNTVP 436_ CRKFV 441_ KINNS 446_ TNEGM 451_ NVKKC 456_ CKGFC 461_ IDILK 466_ KLSRT 471_ VKFTY 476_ DLYLV 481_ TNGKH 486_ GKKVN 491_ NVWNG 496_ MIGEV 501_ VYQRA 506_ VMAVG 511_ SLTIN 516_ EERSE 521_ VVDFS 526_ VPFVE 531_ TGISV 536_ MVSRS 541_ NGTVS 546_ PSAFL 551_ EPFSA 556_ SVWVM 561_ MFVML 566_ LIVSA 571_ IAVFV 576_ FEYFS 581_ PVGYN 586_ RNLAK 591_ GKAPH 596_ GPSFT 601_ IGKAI 606_ WLLWG 611_ LVFNN 616_ SVPVQ 621_ NPKGT 626_ TSKIM 631_ VSVWA 636_ FFAVI 641_ FLASY 646_ TANLA 651_ AFMIQ 656_ EEFVD 661_ QVTGL 666_ SDKKF 671_ QRPHD 676_ YSPPF 681_ RFGTV 686_ PNGST 691_ ERNIR 696_ NNYPY 701_ MHQYM 706_ TKFNQ 711_ KGVED 716_ ALVSL 721_ KTGKL 726_ DAFIY 731_ DAAVL 736_ NYKAG 741_ RDEGC 746_ KLVTI 751_ GSGYI 756_ FATTG 761_ YGIAL 766_ QKGSP 771_ WKRQI 776_ DLALL 781_ QFVGD 786_ GEMEE 791_ LETLW 796_ LTGIC 801_ HNEKN 806_ EVMSS 811_ QLDID 816_ NMAGV 821_ FYMLA 826_ AAMAL 831_ SLITF 836_ IWEHL 841_ FYWKL 846_ RFCFT 851_ GVCSD 856_ RPGLL 861_ FSISR 866_ GIYSC 871_ IHGVH 876_ IEEKK 881_ KSPDF 886_ NLTGS 891_ QSNML 896_ KLLRS 901_ AKNIS 906_ SMSNM 911_ NSSRM 916_ DSPKR 921_ AADFI 926_ QRGSL 931_ IMDMV 936_ SDKGN 941_ LMYSD 946_ NRSFQ 951_ GKESI 956_ FGDNM 961_ NELQT 966_ FVANR 971_ QKDNL 976_ NNYVF 981_ QGQHP 986_ LTLNE 991_ SNPNT 996_ VEVAV 1001_ STESK 1006_ ANSRP 1011_ RQLWK 1016_ KSVDS 1021_ IRQDS 1026_ LSQNP 1031_ VSQRD 1036_ EATAE 1041_ NRTHS 1046_ LKSPR 1051_ YLPEE 1056_ MAHSD 1061_ ISETS 1066_ NRATC 1071_ HREPD 1076_ NSKNH 1081_ KTKDN 1086_ FKRSV 1091_ ASKYP 1096_ KDCSE 1101_ VERTY 1106_ LKTKS 1111_ SSPRD 1116_ KIYTI 1121_ DGEKE 1126_ PGFHL 1131_ DPPQF 1136_ VENVT 1141_ LPENV 1146_ DFPDP 1151_ YQDPS 1156_ ENFRK 1161_ GDSTL 1166_ PMNRN 1171_ PLHNE 1176_ EGLSN 1181_ NDQYK 1186_ LYSKH 1191_ FTLKD 1196_ KGSPH 1201_ SETSE 1206_ RYRQN 1211_ STHCR 1216_ SCLSN 1221_ MPTYS 1226_ GHFTM 1231_ RSPFK 1236_ CDACL 1241_ RMGNL 1246_ YDIDE 1251_ DQMLQ 1256_ ETGNP 1261_ ATGEQ 1266_ VYQQD 1271_ WAQNN 1276_ ALQLQ 1281_ KNKLR 1286_ ISRQH 1291_ SYDNI 1296_ VDKPR 1301_ ELDLS 1306_ RPSRS 1311_ ISLKD 1316_ RERLL 1321_ EGNFY 1326_ GSLFS 1331_ VPSSK 1336_ LSGKK 1341_ SSLFP 1346_ QGLED 1351_ SKRSK 1356_ SLLPD 1361_ HTSDN 1366_ PFLHS 1371_ HRDDQ 1376_ RLVIG 1381_ RCPSD 1386_ PYKHS 1391_ LPSQA 1396_ VNDSY 1401_ LRSSL 1406_ RSTAS 1411_ YCSRD 1416_ SRGHN 1421_ DVYIS 1426_ EHVMP 1431_ YAANK 1436_ NNMYS 1441_ TPRVL 1446_ NSCSN 1451_ RRVYK 1456_KMPSI
1: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity)