Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)
1_MAPVL 6_ SKDSA 11_ DIESI 16_ LALNP 21_ RTQTH 26_ ATLCS 31_ TSAKK 36_ LDKKH 41_ WKRNP 46_ DKNCF 51_ NCEKL 56_ ENNFD 61_ DIKHT 66_ TLGER 71_ GALRE 76_ AMRCL 81_ KCADA 86_ PCQKS 91_ CPTNL 96_ DIKSF 101_ ITSIA 106_ NKNYY 111_ GAAKM 116_ IFSDN 121_ PLGLT 126_ CGMVC 131_ PTSDL 136_ CVGGC 141_ NLYAT 146_ EEGPI 151_ NIGGL 156_ QQFAT 161_ EVFKA 166_ MSIPQ 171_ IRNPS 176_ LPPPE 181_ KMSEA 186_ YSAKI 191_ ALFGA 196_ GPASI 201_ SCASF 206_ LARLG 211_ YSDIT 216_ IFEKQ 221_ EYVGG 226_ LSTSE 231_ IPQFR 236_ LPYDV 241_ VNFEI 246_ ELMKD 251_ LGVKI 256_ ICGKS 261_ LSVNE 266_ MTLST 271_ LKEKG 276_ YKAAF 281_ IGIGL 286_ PEPNK 291_ DAIFQ 296_ GLTQD 301_ QGFYT 306_ SKDFL 311_ PLVAK 316_ GSKAG 321_ MCACH 326_ SPLPS 331_ IRGVV 336_ IVLGA 341_ GDTAF 346_ DCATS 351_ ALRCG 356_ ARRVF 361_ IVFRK 366_ GFVNI 371_ RAVPE 376_ EMELA 381_ KEEKC 386_ EFLPF 391_ LSPRK 396_ VIVKG 401_ GRIVA 406_ MQFVR 411_ TEQDE 416_ TGKWN 421_ EDEDQ 426_ MVHLK 431_ ADVVI 436_ SAFGS 441_ VLSDP 446_ KVKEA 451_ LSPIK 456_ FNRWG 461_ LPEVD 466_ PETMQ 471_ TSEAW 476_ VFAGG 481_ DVVGL 486_ ANTTV 491_ ESVND 496_ GKQAS 501_ WYIHK 506_ YVQSQ 511_ YGASV 516_ SAKPE 521_ LPLFY 526_ TPIDL 531_ VDISV 536_ EMAGL 541_ KFINP 546_ FGLAS 551_ ATPAT 556_ STSMI 561_ RRAFE 566_ AGWGF 571_ ALTKT 576_ FSLDK 581_ DIVTN 586_ VSPRI 591_ IRGTT 596_ SGPMY 601_ GPGQS 606_ SFLNI 611_ ELISE 616_ KTAAY 621_ WCQSV 626_ TELKA 631_ DFPDN 636_ IVIAS 641_ IMCSY 646_ NKNDW 651_ TELAK 656_ KSEDS 661_ GADAL 666_ ELNLS 671_ CPHGM 676_ GERGM 681_ GLACG 686_ QDPEL 691_ VRNIC 696_ RWVRQ 701_ AVQIP 706_ FFAKL 711_ TPNVT 716_ DIVSI 721_ ARAAK 726_ EGGAN 731_ GVTAT 736_ NTVSG 741_ LMGLK 746_ SDGTP 751_ WPAVG 756_ IAKRT 761_ TYGGV 766_ SGTAI 771_ RPIAL 776_ RAVTS 781_ IARAL 786_ PGFPI 791_ LATGG 796_ IDSAE 801_ SGLQF 806_ LHSGA 811_ SVLQV 816_ CSAIQ 821_ NQDFT 826_ VIEDY 831_ CTGLK 836_ ALLYL 841_ KSIEE 846_ LQDWD 851_ GQSPA 856_ TVSHQ 861_ KGKPV 866_ PRIAE 871_ LMDKK 876_ LPSFG 881_ PYLEQ 886_ RKKII 891_ AENKI 896_ RLKEQ 901_ NVAFS 906_ PLKRN 911_ CFIPK 916_ RPIPT 921_ IKDVI 926_ GKALQ 931_ YLGTF 936_ GELSN 941_ VEQVV 946_ AMIDE 951_ EMCIN 956_ CGKCY 961_ MTCND 966_ SGYQA 971_ IQFDP 976_ ETHLP 981_ TITDT 986_ CTGCT 991_ LCLSV 996_ CPIVD 1001_ CIKMV 1006_ SRTTP 1011_ YEPKR 1016_GVPLS
1: Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248)