Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]
1_MKTWV 6_ KIVFG 11_ VATSA 16_ VLALL 21_ VMCIV 26_ LRPSR 31_ VHNSE 36_ ENTMR 41_ ALTLK 46_ DILNG 51_ TFSYK 56_ TFFPN 61_ WISGQ 66_ EYLHQ 71_ SADNN 76_ IVLYN 81_ IETGQ 86_ SYTIL 91_ SNRTM 96_ KSVNA 101_ SNYGL 106_ SPDRQ 111_ FVYLE 116_ SDYSK 121_ LWRYS 126_ YTATY 131_ YIYDL 136_ SNGEF 141_ VRGNE 146_ LPRPI 151_ QYLCW 156_ SPVGS 161_ KLAYV 166_ YQNNI 171_ YLKQR 176_ PGDPP 181_ FQITF 186_ NGREN 191_ KIFNG 196_ IPDWV 201_ YEEEM 206_ LATKY 211_ ALWWS 216_ PNGKF 221_ LAYAE 226_ FNDTD 231_ IPVIA 236_ YSYYG 241_ DEQYP 246_ RTINI 251_ PYPKA 256_ GAKNP 261_ VVRIF 266_ IIDTT 271_ YPAYV 276_ GPQEV 281_ PVPAM 286_ IASSD 291_ YYFSW 296_ LTWVT 301_ DERVC 306_ LQWLK 311_ RVQNV 316_ SVLSI 321_ CDFRE 326_ DWQTW 331_ DCPKT 336_ QEHIE 341_ ESRTG 346_ WAGGF 351_ FVSTP 356_ VFSYD 361_ AISYY 366_ KIFSD 371_ KDGYK 376_ HIHYI 381_ KDTVE 386_ NAIQI 391_ TSGKW 396_ EAINI 401_ FRVTQ 406_ DSLFY 411_ SSNEF 416_ EEYPG 421_ RRNIY 426_ RISIG 431_ SYPPS 436_ KKCVT 441_ CHLRK 446_ ERCQY 451_ YTASF 456_ SDYAK 461_ YYALV 466_ CYGPG 471_ IPIST 476_ LHDGR 481_ TDQEI 486_ KILEE 491_ NKELE 496_ NALKN 501_ IQLPK 506_ EEIKK 511_ LEVDE 516_ ITLWY 521_ KMILP 526_ PQFDR 531_ SKKYP 536_ LLIQV 541_ YGGPC 546_ SQSVR 551_ SVFAV 556_ NWISY 561_ LASKE 566_ GMVIA 571_ LVDGR 576_ GTAFQ 581_ GDKLL 586_ YAVYR 591_ KLGVY 596_ EVEDQ 601_ ITAVR 606_ KFIEM 611_ GFIDE 616_ KRIAI 621_ WGWSY 626_ GGYVS 631_ SLALA 636_ SGTGL 641_ FKCGI 646_ AVAPV 651_ SSWEY 656_ YASVY 661_ TERFM 666_ GLPTK 671_ DDNLE 676_ HYKNS 681_ TVMAR 686_ AEYFR 691_ NVDYL 696_ LIHGT 701_ ADDNV 706_ HFQNS 711_ AQIAK 716_ ALVNA 721_ QVDFQ 726_ AMWYS 731_ DQNHG 736_ LSGLS 741_ TNHLY 746_ THMTH 751_FLKQC
1: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16410248, PubMed:16480718, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vitronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711, PubMed:2172980, PubMed:7923219, PubMed:9065413). Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16410248, PubMed:16651416, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner